AMPICILLIN CONCENTRATIONS IN HUMAN-SERUM AND PERIODONTAL MEMBRANE FOLLOWING A SINGLE ORAL-ADMINISTRATION OF BACAMPICILLIN

Ampicillin concentrations in human serum and periodontal membrane after a single oral administration of bacampicillin (500 mg) were assayed by the agar diffusion (paper disc) method. The peak times of serum and peridontal membrane were nearly identical, being approx. 90 min after administration. The peak concentrations of serum and periodontal membrane were 12.81 .mu.g/ml and 6.97 .mu.g/g, respectively. The concentration ratio of periodontal membrane to serum at the peak time was 0.56.