SUPPRESSION BY IL-2 OF IGE PRODUCTION BY B-CELLS STIMULATED BY IL-4

被引:0
|
作者
MIYAJIMA, H
HIRANO, T
HIROSE, S
KARASUYAMA, H
OKUMURA, K
OVARY, Z
机构
[1] JUNTENDO UNIV,SCH MED,DIV PATHOBIOL,TOKYO 113,JAPAN
[2] JUNTENDO UNIV,SCH MED,DIV RHEUMATOL & INTERNAL MED,TOKYO 113,JAPAN
[3] KAPLAN CANC CTR,NEW YORK,NY
[4] UNIV TOKYO,SCH MED,DEPT IMMUNOL,TOKYO 113,JAPAN
[5] NYU,SCH MED,DEPT PATHOL,NEW YORK,NY 10003
来源
JOURNAL OF IMMUNOLOGY | 1991年 / 146卷 / 02期
关键词
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
IgE production was obtained from B cells of BALB/c or nude mice when these cells were cultured with IL-4 plus LPS. IL-2 added to these cultures at the start (day 0), 1 or 2 days later completely suppressed the production of IgE. The production of IgG1 was also inhibited, but only if IL-2 was added on day 0. The production of other isotypes (IgM, IgG2a, IgG2b) was only slightly decreased by addition of IL-2. No suppression of IgE or IgG1 production was observed if monoclonal anti-IL-2 was added, whereas anti-IFN-gamma had no effect on the suppression of the production of these isotypes. The expression of CD23 on the third day of culture on B cells stimulated with LPS and IL-4 was markedly decreased when IL-2 was added to the cultures on day 0. Addition of monoclonal anti-IL-2 suppressed all effects produced by IL-2, whereas addition of anti-IFN-gamma had no effect. These results show that the suppression by IL-2, at least for the first signaling processes, are different from the suppression produced by IFN-gamma.
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页码:457 / 462
页数:6
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