CA2+ HOMEOSTASIS IN VASCULAR SMOOTH-MUSCLE

被引：75
|
作者：
HIMPENS, B
MISSIAEN, L
CASTEELS, R
机构：
[1] Physiological Laboratory, K.U. Leuven, Leuven
来源：
JOURNAL OF VASCULAR RESEARCH | 1995年 / 32卷 / 04期
关键词：
INS P-3 RECEPTOR; RYANODINE RECEPTOR; SMOOTH MUSCLE; NUCLEAR CA2+; CULTURED CELLS;
D O I：
10.1159/000159095
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The free intracellular calcium concentration is an important link in the excitation-contraction coupling mechanism of vascular smooth muscle. In this review, some current topics about vascular smooth muscle as regards Ca2+ storage, Ca2+ release, Ca2+ extrusion and Ca2+ regulation are discussed. Particular attention is paid to Ca2+ mobilized from the sarcoplasmic reticulum, the physiologically important Ca2+ reservoir in vascular smooth muscle. This occurs through two Ca2+ release channels: the inositol 1,4,5-trisphosphate receptor and the ryanodine receptor; the characteristics, function and control of these two receptors are summarized. Emphasis is also placed on a role of the nucleus as a potential Ca2+ storage site.
引用
收藏
页码：207 / 219
页数：13
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