SUBPOPULATIONS OF GABA-MEDIATED SYNAPTIC POTENTIALS IN SLICES OF RAT DORSAL STRIATUM ARE DIFFERENTIALLY MODULATED BY PRESYNAPTIC GABA-B RECEPTORS

被引：34

作者：

SEABROOK, GR ^{[1
]}

HOWSON, W ^{[1
]}

LACEY, MG ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,WELWYN GARDEN CIT,HERTS,ENGLAND

来源：

BRAIN RESEARCH | 1991年 / 562卷 / 02期

关键词：

BACLOFEN; GAMMA-AMINOBUTYRIC ACID; CAUDATE-PUTAMEN; GAMMA-AMINOBUTYRIC ACID RECEPTOR ELECTROPHYSIOLOGY; PRESYNAPTIC INHIBITION;

D O I：

10.1016/0006-8993(91)90642-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Gamma-Aminobutyric acid (GABA)-mediated synaptic potentials in rat dorsal striatum in vitro were reduced in amplitude by the GABA(B) receptor agonists baclofen and 3-aminopropyl-(methyl)-phosphinic acid (SK&F 97541), without any detectable postsynaptic effect. Synaptic potentials in 40% of neurones were distinctly multiphasic, the components of which exhibited a differential sensitivity to GABA(B) agonists. One population of GABA-releasing neurones within the striatum had presynaptic GABA(B) autoreceptors, whereas others were not directly affected by GABA(B) agonists.

引用

页码：332 / 334

页数：3

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