SUBPOPULATIONS OF GABA-MEDIATED SYNAPTIC POTENTIALS IN SLICES OF RAT DORSAL STRIATUM ARE DIFFERENTIALLY MODULATED BY PRESYNAPTIC GABA-B RECEPTORS

被引：34
|
作者：
SEABROOK, GR [1 ]
HOWSON, W [1 ]
LACEY, MG [1 ]
机构：
[1] SMITHKLINE BEECHAM PHARMACEUT,WELWYN GARDEN CIT,HERTS,ENGLAND
来源：
BRAIN RESEARCH | 1991年 / 562卷 / 02期
关键词：
BACLOFEN; GAMMA-AMINOBUTYRIC ACID; CAUDATE-PUTAMEN; GAMMA-AMINOBUTYRIC ACID RECEPTOR ELECTROPHYSIOLOGY; PRESYNAPTIC INHIBITION;
D O I：
10.1016/0006-8993(91)90642-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Gamma-Aminobutyric acid (GABA)-mediated synaptic potentials in rat dorsal striatum in vitro were reduced in amplitude by the GABA(B) receptor agonists baclofen and 3-aminopropyl-(methyl)-phosphinic acid (SK&F 97541), without any detectable postsynaptic effect. Synaptic potentials in 40% of neurones were distinctly multiphasic, the components of which exhibited a differential sensitivity to GABA(B) agonists. One population of GABA-releasing neurones within the striatum had presynaptic GABA(B) autoreceptors, whereas others were not directly affected by GABA(B) agonists.
引用
收藏
页码：332 / 334
页数：3
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