DIRECT EFFECTS OF BROMOCRIPTINE ON THE STEROIDOGENIC CAPABILITY OF PORCINE GRANULOSA-CELLS

被引：3
|
作者：
KAMADA, S
KUBOTA, T
TAGUCHI, M
ASO, T
机构：
[1] Dept. of Obstetrics and Gynecology, Tokyo Medical/Dental University, Faculty of Medicine, Bunkyo-ku, Tokyo 113
来源：
ACTA ENDOCRINOLOGICA | 1992年 / 126卷 / 04期
关键词：
D O I：
10.1530/acta.0.1260338
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The direct effects of bromocriptine on steroidogenesis were examined in cultured porcine granulosa cells. The following observations were made with bromocriptine: (1) It significantly increased the basal or FSH-stimulated secretion of progesterone in cultured porcine granulosa cells at concentrations exceeding 10(-7) mol/l: (2) its inhibitory effect on basal estradiol secretion was demonstrated; (3) it did not influence cell number in cultured porcine granulosa cells: (4) it increased the extracellular accumulation of cAMP in a concentration-dependent manner; and (5) it did not induce a change in cytosolic free Ca2+ concentration. These findings suggest that bromocriptine exerts a direct effect on steroidogenesis in ovarian granulosa cells.
引用
收藏
页码：338 / 344
页数：7
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