ANTIHEPATOTOXIC ACTIVITY OF PHENOLIC FLAVAN-3-OLS AND THEIR DERIVATIVES

被引：4
|
作者：
HSU, FL
TSAI, YJ
KAO, MC
CHEN, CF
机构：
[1] Graduate Institute of Pharmaceutical Sciences, Taipei Medical College
来源：
AMERICAN JOURNAL OF CHINESE MEDICINE | 1993年 / 21卷 / 01期
关键词：
D O I：
10.1142/S0192415X93000066
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
The protective activity against carbon tetrachloride induced hepatotoxicity of several phenolic flavan-3-ols and their derivatives has been assessed. Our research showed that monomers possessing a pyrogallol moiety as the B-ring had greater activity and this was not directly related to the stereo-chemistry of the hydroxyl group at C-3 in the flavan unit. However, when a galloyl group was linked to the hydroxyl group to form a gallate, this product exhibited markedly more activity than other analogs. These results suggest that the antihepatotoxic activity of phenolic flavan-3-ols and their derivatives seem to be related to the galloylation at the C-3 hydroxyl group in the flavan skeleton rather than the structure of another moiety or the degree of condensation.
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收藏
页码：45 / 50
页数：6
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