INDUCTION OF LIPID ASYMMETRY AND EXCHANGE IN MODEL MEMBRANE SYSTEMS

被引：1
|
作者：
TILCOCK, C
EASTMAN, S
FISHER, D
机构：
[1] UNIV BRITISH COLUMBIA,DEPT BIOCHEM,VANCOUVER V6T 1W5,BC,CANADA
[2] UNIV LONDON,ROYAL FREE HOSP,SCH MED,DEPT BIOCHEM,LONDON NW3 2PF,ENGLAND
[3] UNIV LONDON,ROYAL FREE HOSP,SCH MED,MOLEC CELL PATHOL LAB,LONDON NW3 2PF,ENGLAND
来源：
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 1991年 / 12卷 / 02期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1080/01932699108913116
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Negatively-charged lipids such as fatty acids, mono- and diacyl phosphatidylglycerol, diacyl phosphatidic acid and cardiolipin redistribute across a lipid bilayer in response to an applied pH gradient to accumulate on the high pH side of the membrane thereby forming bilayers that are asymmetric with respect to lipid composition. A novel general procedure for the quantitative assessment of lipid asymmetry has been developed, based upon partition in aqueous two-phase polymer systems. Herein several examples are provided to demonstrate the utility of the partition method. The effects of temperature and lipid composition upon both the rate of formation and extent of asymmetry in model systems are described. Finally an example of one system is given in which the interaction between two membrane surfaces is modulated by the lipid asymmetry of the membranes.
引用
下载
收藏
页码：129 / 144
页数：16
相关论文
共 50 条
  • [41] COLLAGEN-INDUCED CHANGES IN PLATELET MEMBRANE LIPID ASYMMETRY
    BOESZEBATTAGLIA, K
    SCHIMMELL, RJ
    BIOPHYSICAL JOURNAL, 1994, 66 (02) : A60 - A60
  • [42] Mechanism for sensing lipid asymmetry of the plasma membrane and external alkalization
    Obara, Keisuke
    Nishino, Kanako
    Kihara, Akio
    YEAST, 2015, 32 : S195 - S195
  • [43] Preparation of Artificial Plasma Membrane Mimicking Vesicles with Lipid Asymmetry
    Lin, Qingqing
    London, Erwin
    PLOS ONE, 2014, 9 (01):
  • [44] Measurements of the effect of membrane asymmetry on the mechanical properties of lipid bilayers
    Elani, Yuval
    Purushothaman, Sowmya
    Booth, Paula J.
    Seddon, John M.
    Brooks, Nicholas J.
    Law, Robert V.
    Ces, Oscar
    CHEMICAL COMMUNICATIONS, 2015, 51 (32) : 6976 - 6979
  • [45] PHOSPHOLIPID ASYMMETRY AND LIPID TRANSPORT IN RED-CELL MEMBRANE
    ZACHOWSKI, A
    MORROT, G
    HERRMANN, A
    FELLMANN, P
    HERVE, P
    DEVAUX, PF
    STUDIA BIOPHYSICA, 1989, 134 (1-2): : 11 - 16
  • [46] Structural basis for maintenance of bacterial outer membrane lipid asymmetry
    Abellon-Ruiz, Javier
    Kaptan, Shreyas S.
    Basle, Arnaud
    Claudi, Beatrice
    Bumann, Dirk
    Kleinekathoefer, Ulrich
    van den Berg, Bert
    NATURE MICROBIOLOGY, 2017, 2 (12): : 1616 - 1623
  • [47] DIENE CONJUGATION AND PEROXIDE FORMATION IN MODEL LIPID-MEMBRANE SYSTEMS
    RALEIGH, JA
    KREMERS, W
    RADIATION RESEARCH, 1976, 67 (03) : 516 - 516
  • [48] Stabilizing Leaflet Asymmetry under Differential Stress in a Highly Coarse-Grained Lipid Membrane Model
    Foley, Samuel
    Deserno, Markus
    JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 2020, 16 (11) : 7195 - 7206
  • [49] EFFECTS OF FIBRINOGENS ON PHASE-TRANSITIONS IN LIPID MODEL MEMBRANE SYSTEMS
    CUNNINGHAM, BA
    KUCUK, O
    KWAAN, HC
    WESTERMAN, MP
    TRACY, D
    LIS, LJ
    CHEMISTRY AND PHYSICS OF LIPIDS, 1994, 72 (01) : 1 - 6
  • [50] Structure and lipid dynamics in the maintenance of lipid asymmetry inner membrane complex of A. baumannii
    Mann, Daniel
    Fan, Junping
    Somboon, Kamolrat
    Farrell, Daniel P.
    Muenks, Andrew
    Tzokov, Svetomir B.
    DiMaio, Frank
    Khalid, Syma
    Miller, Samuel, I
    Bergeron, Julien R. C.
    COMMUNICATIONS BIOLOGY, 2021, 4 (01)
12345