STRUCTURAL STUDIES OF INTERMEDIATES IN THE SYNTHESIS OF MIFEPRISTONE (RU-486) .2. STRUCTURE OF A BETA-EPOXY STEROID

被引：0
|
作者：
SAGAR, MB [1 ]
RAVIKUMAR, K [1 ]
RAO, AVR [1 ]
REDDY, MM [1 ]
SINGH, AK [1 ]
机构：
[1] INDIAN INST CHEM TECHNOL, BIOORGAN LAB, HYDERABAD 500007, ANDHRA PRADESH, INDIA
来源：
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY | 1995年 / 51卷
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D O I：
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中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Structure determination of the title compound, 5 beta,10 beta-epoxy-3,3-ethylenedioxy-17 beta-hydroxy-17 alpha-(1-propynyl)estra-9 (Il)-ene, C23H30O4, establishes the configuration of the epoxy O atom as 5 beta,10 beta and locates the position of the double bond between C(9) and C(11). The strain caused by the presence of an epoxy O atom between C(5) and C(10) in the molecule is reflected in the distortion of bond angles around several tetrahedral C atoms. The propynyl group is oriented perpendicular to the steroid skeleton. The molecules are hydrogen-bonded head-to-tail through hydroxyl groups.
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页码：451 / 454
页数：4
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