STRUCTURAL STUDIES OF INTERMEDIATES IN THE SYNTHESIS OF MIFEPRISTONE (RU-486) .2. STRUCTURE OF A BETA-EPOXY STEROID

被引：0

作者：

SAGAR, MB ^{[1
]}

RAVIKUMAR, K ^{[1
]}

RAO, AVR ^{[1
]}

REDDY, MM ^{[1
]}

SINGH, AK ^{[1
]}

机构：

[1] INDIAN INST CHEM TECHNOL, BIOORGAN LAB, HYDERABAD 500007, ANDHRA PRADESH, INDIA

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY | 1995年 / 51卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Structure determination of the title compound, 5 beta,10 beta-epoxy-3,3-ethylenedioxy-17 beta-hydroxy-17 alpha-(1-propynyl)estra-9 (Il)-ene, C23H30O4, establishes the configuration of the epoxy O atom as 5 beta,10 beta and locates the position of the double bond between C(9) and C(11). The strain caused by the presence of an epoxy O atom between C(5) and C(10) in the molecule is reflected in the distortion of bond angles around several tetrahedral C atoms. The propynyl group is oriented perpendicular to the steroid skeleton. The molecules are hydrogen-bonded head-to-tail through hydroxyl groups.

引用

页码：451 / 454

页数：4

共 32 条

[1] STRUCTURAL STUDIES OF INTERMEDIATES IN THE SYNTHESIS OF MIFEPRISTONE (RU-486) .4. AN ALPHA-EPOXY STEROID
BIDYASAGAR, M
RAVIKUMAR, K
RAO, AVR
REDDY, MM
SINGH, AK
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 1995, 51 : 2102 - 2105
[2] Structural studies of intermediates in the synthesis of mifepristone (RU 486). II. Structure of a β-epoxy steroid
Bidya, Sagar, M.
Ravikumar, K.
Rama Rao, A.V.
Machender Reddy, M.
Singh, A.K.
Acta Crystallographica, Section C: Crystal Structure Communications, 1995, 51 (pt 3):
[3] STRUCTURAL STUDIES OF INTERMEDIATES IN THE SYNTHESIS OF MIFEPRISTONE (RU-486) .1. AN 11-BETA-SUBSTITUTED STEROID
BIDYASAGAR, M
RAVIKUMAR, K
RAMA, RAV
REDDY, MM
SINGH, AK
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 1994, 50 : 2089 - 2093
[4] Structural studies of intermediates in the synthesis of mifepristone (RU 486). IV. An α-epoxy steroid
Bidyasagar, M.
Ravikumar, K.
Rao, A.V. Rama
Reddy, M.M.
Singh, A.K.
Acta Crystallographica, Section C: Crystal Structure Communications, 1995, 51 (pt 10):
[5] STRUCTURAL STUDIES OF INTERMEDIATES IN THE SYNTHESIS OF MIFEPRISTONE (RU-486) .3. 3,3-ETHYLENEDIOXY-5(10),9(11)-ESTRADIEN-17-ONE
BIDYASAGAR, M
RAVIKUMAR, K
RAO, AVR
SARMA, BVNBS
SINGH, AK
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 1995, 51 : 1327 - 1330
[6] ALPHA,BETA-EPOXY SULFOXIDES AS USEFUL INTERMEDIATES IN ORGANIC-SYNTHESIS .2. A NOVEL SYNTHESIS OF ALPHA-SULFENYLATED KETONES AND ALPHA-SULFENYLATED ALDEHYDES FROM ALPHA,BETA-EPOXY SULFOXIDES
SATOH, T
KUMAGAWA, T
YAMAKAWA, K
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1985, 58 (10) : 2849 - 2854
[7] THE PLACENTAL-TRANSFER OF MIFEPRISTONE (RU-486) DURING THE 2ND TRIMESTER AND ITS INFLUENCE UPON MATERNAL AND FETAL STEROID CONCENTRATIONS
HILL, NCW
SELINGER, M
FERGUSON, J
MACKENZIE, IZ
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1990, 97 (05): : 406 - 411
[8] Structural studies of intermediates in the synthesis of mifepristone (RU 486). III. 3,3-ethylenedioxy-5(10),9(II)-estradien-17-one
Bidyasagar, M.
Ravikumar, K.
Rama Rao, A.V.
Sarma, B.V.N.B.S.
Singh, A.K.
Acta Crystallographica, Section C: Crystal Structure Communications, 1995, 51 (pt 7):
[9] ALPHA,BETA-EPOXY SULFOXIDES AS USEFUL INTERMEDIATES IN ORGAN SYNTHESIS .11. INTRAMOLECULAR RING-CLOSURE OF ALPHA,BETA-EPOXY SULFOXIDES WITH HYDROXYL GROUP - A NOVEL SYNTHESIS OF 2-ACYL CYCLIC ETHERS AND 3-KETO CYCLIC ETHERS
SATOH, T
IWAMOTO, K
YAMAKAWA, K
TETRAHEDRON LETTERS, 1987, 28 (23) : 2603 - 2606
[10] STUDIES IN STEROID TOTAL SYNTHESIS .2. CORRELATION OF OPTICALLY ACTIVE BICYCLIC INTERMEDIATES WITH NATURAL STEROIDS
BARKLEY, LB
FARRAR, MW
KNOWLES, WS
RAFFELSON, H
THOMPSON, QE
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1954, 76 (20) : 5014 - 5016

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