Anti-Influenza Antibody Level After Vaccination In North Of Iran

Objective: Influenza is a highly transmitted disease and about 10% of the world's population is affected by this disease annually. The aim of this research was to study the variation of serum antibody levels among subjects who had already been vaccinated against influenza. Methods And Materials: This descriptive-analytical study was carried out on 196 subjects who had influenza vaccination (influvac 2005/2006) and on 200 subjects who were matched with the vaccinated subjects by their ages in Gorgan which is located in the northeast of Iran. The subject's sera were prepared seven weeks after the influenza vaccination. Their serum antibody levels were determinated by the heamaglutination inhibition test. Results: The antibody titre in 81 subjects of the vaccinated group and in 175 subjects of the control group was less then 1/40. The mean antibody titre of the vaccinated subjects and the control group was 143.4 +/- 10.89 and 18.34 +/- 3.2, respectively. The difference was statistically significant (P value=0.000). Conclusion: The findings showed that the mean titre of the antibodies in the vaccinated and control groups was statistically different. This means that the influenza vaccine has good efficacy in our population.