ASYMMETRIC REDUCTION OF 2-AMINOBENZOPHENONE USING YEAST, RHODOSPORIDIUM-TORULOIDES

被引：0
|
作者：
KATO, M
SASAHARA, K
OCHI, K
AKITA, H
OISHI, T
机构：
[1] TOHO UNIV, SCH PHARMACEUT SCI, FUNABASHI, CHIBA 274, JAPAN
[2] INST PHYS & CHEM RES, SYNTHET ORGAN CHEM LAB, WAKO, SAITAMA 351, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1991年 / 39卷 / 10期
关键词：
2-AMINOBENZOPHENONE; 2-AMINOBENZHYDROL; ASYMMETRIC REDUCTION; MICROBIOLOGICAL REDUCTION; YEAST;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
(+/-)-N-Isonicotinoyl-2-amino-5-chlorobenzhydrol (1) is a rice plant growth regulator which shortens the second leaf sheaths. One of the enantiomers, (S)-1, was obtained by microbiological asymmetric reduction of 2-amino-5-chlorobenzophenone using Rhodosporidium toruloides followed by isonicotinoylation. Several substituted benzhydrol derivatives were also prepared by use of the same biological method and converted to N-isonicotinoyl compounds. The growth-regulating activities of these compounds were evaluated.
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页码：2498 / 2501
页数：4
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