OKT4 EPITOPE DEFICIENCY IN PATIENTS INFECTED WITH THE HUMAN-IMMUNODEFICIENCY-VIRUS - A CAUSE OF UNDERESTIMATION OF THE CD4 LYMPHOCYTE COUNT

被引：2
|
作者：
KHUONG, MA
CARAGE, T
KOMAROVER, H
MECHALI, D
机构：
[1] HOP DELAFONTAINE,INFECT DIS UNIT,ST DENIS,FRANCE
[2] HOP DELAFONTAINE,DEPT HEMATOL,ST DENIS,FRANCE
[3] HOP AVICENNE,CTR DEPT TRANSFUS SANGUINE,BOBIGNY,FRANCE
来源：
CLINICAL INFECTIOUS DISEASES | 1994年 / 19卷 / 05期
关键词：
D O I：
10.1093/clinids/19.5.961
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Two black patients who were infected with the human immunodeficiency virus (HIV) and who had hereditary deficiency of OKT4 epitope were investigated. The patients' lymphocytes lacked the OKT4 surface antigen but reacted with other monoclonal antibodies recognizing the CD4+ helper-inducer T lymphocytes. The CD4 lymphocyte count is a surrogate marker for clinical progression of HIV disease, but it could be unreliable in regard to patients with partial or complete OKT4 epitope deficiency.
引用
收藏
页码：961 / 963
页数：3
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