Cancer stem cells in melanoma

被引：4
|
作者：
Regenbrecht, C. [1 ]
Welte, Y. [2 ]
Hugel, R. [2 ]
Trefzer, U. [2 ]
Losch, F. O. [2 ]
Adjaye, J. [1 ]
Walden, P. [2 ]
机构：
[1] Max Planck Inst Mol Genet, Berlin, Germany
[2] Charite, Dept Dermatol, Clin Res Grp Tumour Immunol, Berlin, Germany
来源：
ECANCERMEDICALSCIENCE | 2008年 / 2卷
关键词：
D O I：
10.3332/ecancer.2008.114
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The identification of cancer stem cells in various malignancies led to the hypothesis that these cells have the exclusive ability of self-renewal, contribute to the plasticity of the tumours and may be the cause for ineffective cancer therapies. Several markers of melanoma stem cells have been described in recent studies including CD133, CD166, Nestin and BMI-1. Further studies are necessary to identify, better define and understand the origin and function of cancer stem cells. If confirmed that cancer stem cells play an important role in malignancy, therapeutic strategies may need to be redirected towards these cells to circumvent the failure of conventional therapies.
引用
收藏
页数：6
相关论文
共 50 条
  • [41] Understanding melanoma stem cells
    Nguyen, Nicholas
    Couts, Kasey L.
    Luo, Yuchun
    Fujita, Mayumi
    [J]. MELANOMA MANAGEMENT, 2015, 2 (02) : 179 - 188
  • [42] CYTOMIC ANALYSIS OF CANCER STEM CELLS IN HUMAN MELANOMA CELL LINES
    Pinto, S.
    Martinez-Romero, A.
    Gil, D.
    O'Connor, J.
    Gil-Benso, R.
    Monteagudo, C.
    Callaghan, R.
    [J]. CELLULAR ONCOLOGY, 2010, 32 (03) : 178 - 178
  • [43] Lunasin is a novel therapeutic agent for targeting melanoma cancer stem cells
    Shidal, Chris
    Al-Rayyan, Numan
    Yaddanapudi, Kavitha
    Davis, Keith R.
    [J]. ONCOTARGET, 2016, 7 (51): : 84128 - 84141
  • [44] Therapeutic implications of cellular and molecular biology of cancer stem cells in melanoma
    Kumar, Dhiraj
    Gorain, Mahadeo
    Kundu, Gautam
    Kundu, Gopal C.
    [J]. MOLECULAR CANCER, 2017, 16
  • [45] The most aggressive melanoma tumors have the most cancer stem cells
    Boonyaralanakornkit, J. B.
    Yue, L.
    Strachan, L. R.
    Fong, S.
    Smith, J.
    Scalapino, K.
    Leong, S. P.
    Ghadially, R.
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2008, 128 : S225 - S225
  • [46] The isolation and characterization of non-melanoma skin cancer stem cells
    Murao, K.
    Buitrago, W.
    Koch, P. J.
    Roop, D. R.
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2008, 128 : S39 - S39
  • [47] Therapeutic implications of cellular and molecular biology of cancer stem cells in melanoma
    Dhiraj Kumar
    Mahadeo Gorain
    Gautam Kundu
    Gopal C. Kundu
    [J]. Molecular Cancer, 16
  • [48] Stem cells, cancer, and cancer stem cells
    Tannishtha Reya
    Sean J. Morrison
    Michael F. Clarke
    Irving L. Weissman
    [J]. Nature, 2001, 414 : 105 - 111
  • [49] Stem cells, cancer, and cancer stem cells
    Reya, T
    Morrison, SJ
    Clarke, MF
    Weissman, IL
    [J]. NATURE, 2001, 414 (6859) : 105 - 111
  • [50] Melanoma stem cells in experimental melanoma are killed by radioimmunotherapy
    Jandl, Thomas
    Revskaya, Ekaterina
    Jiang, Zewei
    Harris, Matthew
    Dorokhova, Olena
    Tsukrov, Dina
    Casadevall, Arturo
    Dadachova, Ekaterina
    [J]. NUCLEAR MEDICINE AND BIOLOGY, 2013, 40 (02) : 177 - 181
12345