Cancer stem cells in melanoma

被引：4
|
作者：
Regenbrecht, C. [1 ]
Welte, Y. [2 ]
Hugel, R. [2 ]
Trefzer, U. [2 ]
Losch, F. O. [2 ]
Adjaye, J. [1 ]
Walden, P. [2 ]
机构：
[1] Max Planck Inst Mol Genet, Berlin, Germany
[2] Charite, Dept Dermatol, Clin Res Grp Tumour Immunol, Berlin, Germany
来源：
ECANCERMEDICALSCIENCE | 2008年 / 2卷
关键词：
D O I：
10.3332/ecancer.2008.114
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The identification of cancer stem cells in various malignancies led to the hypothesis that these cells have the exclusive ability of self-renewal, contribute to the plasticity of the tumours and may be the cause for ineffective cancer therapies. Several markers of melanoma stem cells have been described in recent studies including CD133, CD166, Nestin and BMI-1. Further studies are necessary to identify, better define and understand the origin and function of cancer stem cells. If confirmed that cancer stem cells play an important role in malignancy, therapeutic strategies may need to be redirected towards these cells to circumvent the failure of conventional therapies.
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页数：6
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