TIGHT LINKAGE OF THE RET PROTOONCOGENE WITH THE MULTIPLE ENDOCRINE NEOPLASIA TYPE-2A LOCUS

被引：0
|
作者：
YAMAMOTO, M
MIKI, T
TANAKA, N
MIYA, A
SHIN, E
KARAKAWA, K
KOBAYASHI, T
TAHIRA, T
ISHIZAKA, Y
ITOH, F
NAGAO, M
MORI, T
TAKAI, S
机构：
来源：
JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 1991年 / 21卷 / 03期
关键词：
LINKAGE; LOD SCORE; MEN2A; RET PROTOONCOGENE; RELP (RESTRICTION FRAGMENT LENGTH POLYMORPHISM);
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The ret proto-oncogene has been mapped to 10q11.2 near the MEN2A locus by in situ hybridization. We carried out a linkage study of Japanese multiple endocrine neoplasia type 2A (MEN2A) families using a cosmid clone containing the ret proto-oncogene as probe. Two polymorphic alleles (A1 and A2) could be detected by digesting DNA with EcoRI: allele A1 was detected as a 10 kb fragment and A2 as 5.4 and 4.6 kb fragments. Of 11 Japanese MEN2A families analysed, four were informative, and the maximum lod score was 4.23 at a recombination fraction of 0.00. This result suggests the ret proto-oncogene to be close to the MEN2A gene and therefore possibly to be a useful DNA marker for cloning the latter.
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页码：149 / 152
页数：4
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