TIGHT LINKAGE OF THE RET PROTOONCOGENE WITH THE MULTIPLE ENDOCRINE NEOPLASIA TYPE-2A LOCUS

被引：0

作者：

YAMAMOTO, M

MIKI, T

TANAKA, N

MIYA, A

SHIN, E

KARAKAWA, K

KOBAYASHI, T

TAHIRA, T

ISHIZAKA, Y

ITOH, F

NAGAO, M

MORI, T

TAKAI, S

机构：

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 1991年 / 21卷 / 03期

关键词：

LINKAGE; LOD SCORE; MEN2A; RET PROTOONCOGENE; RELP (RESTRICTION FRAGMENT LENGTH POLYMORPHISM);

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The ret proto-oncogene has been mapped to 10q11.2 near the MEN2A locus by in situ hybridization. We carried out a linkage study of Japanese multiple endocrine neoplasia type 2A (MEN2A) families using a cosmid clone containing the ret proto-oncogene as probe. Two polymorphic alleles (A1 and A2) could be detected by digesting DNA with EcoRI: allele A1 was detected as a 10 kb fragment and A2 as 5.4 and 4.6 kb fragments. Of 11 Japanese MEN2A families analysed, four were informative, and the maximum lod score was 4.23 at a recombination fraction of 0.00. This result suggests the ret proto-oncogene to be close to the MEN2A gene and therefore possibly to be a useful DNA marker for cloning the latter.

引用

页码：149 / 152

页数：4

共 50 条

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