CHANGES IN CNS LEVELS OF SEROTONIN AND ITS METABOLITE IN SART-STRESSED (REPEATEDLY COLD-STRESSED) RATS

被引：30
|
作者：
HATA, T
ITOH, E
KAWABATA, A
机构：
[1] Department of Pharmacology, Faculty of Pharmacy, Kinki University, Kowakae
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1991年 / 56卷 / 01期
关键词：
D O I：
10.1254/jjp.56.101
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Central nervous system levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in SART (specific alternation of rhythm in temperature)-stressed (repeatedly cold-stressed) rats were examined by HPLC-ECD. In SART-stressed rats, the levels of both 5-HT and 5-HIAA decreased in many brain areas. In the spinal cord, only the 5-HT level decreased. Therefore, the ratio of 5-HIAA to 5-HT increased only in the spinal cord. These results suggest that SART-stressed rats have some form of abnormality in the synthetic system of 5-HT.
引用
收藏
页码：101 / 104
页数：4
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