THE CYTOKINE IP-10 IN CHRONIC HBV AND HCV INFECTION

被引：0

作者：

Nikolova, Nina ^{[1
]}

Antonov, Krasimir ^{[1
]}

Jelev, Deian ^{[1
]}

Mateva, Lyudmila ^{[1
]}

Krastev, Zahariy ^{[1
]}

机构：

[1] Med Univ, Clin Gastroenterol, Univ Hosp St Ivan Rilski Sofia, Sofia, Bulgaria

来源：

JOURNAL OF IMAB | 2013年 / 19卷 / 03期

关键词：

IP-10; chronic HCV; HBV infection; response;

D O I：

10.5272/jimab.2013193.442

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: IP-10 it has been studied as a predictor of treatment response in chronic HCV infected patients. The data for the HBV infection are not enough. Aim: To compare IP-10 levels in patients with chronic HBV /CHB/and HCV infection /CHC/and their relation to liver disease and treatment response. Material and methods: 20 patients - with CHC genotype 1 infection /on standard bi-therapy/and 32 patients with CHB /21 pts - NUC; 11 pts - IFN/. Results: The IP-10 did not correlate with sex, age, ALT and liver fibrosis. The basal IP-10 were lower in patients with CHB (p=0,017). There was a difference in IP-10 baseline levels among the HCV patients with or without RVR(p=0,007). A negative correlation was found between basal IP-10 and RVR (r=-0,508; p=0,008). Conclusion: IP-10 could predict virological response in patients with CHC on standard bi-therapy, but not in HBV infected patients on standard therapy.

引用

页码：442 / 447

页数：6

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