DRUGS AND ENDOGENOUS LIGANDS COMPETE FOR RECEPTOR OCCUPANCY

被引：5
|
作者：
COLBURN, WA
机构：
[1] Harris Laboratories, Inc., Clinical Development Division, Phoenix, AZ 85040
来源：
JOURNAL OF CLINICAL PHARMACOLOGY | 1994年 / 34卷 / 12期
关键词：
D O I：
10.1002/j.1552-4604.1994.tb04724.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Dietary and endogenous ligands compete with drugs for receptor occupancy and therefore should be considered during therapeutic interventions and during pharmacokinetic/ pharmacodynamic modeling. When disease is the result of an overabundance of these natural ligands, antibodies and/or their Fab fragments may be useful as therapeutic agents to reverse the effects of the natural ligands.
引用
收藏
页码：1148 / 1152
页数：5
相关论文
共 50 条
  • [21] ENDOGENOUS GABA RECEPTOR LIGANDS IN HYPOPHYSEAL PORTAL BLOOD
    MITCHELL, R
    GRIEVE, G
    DOW, R
    FINK, G
    NEUROENDOCRINOLOGY, 1983, 37 (03) : 169 - 176
  • [22] ENDOGENOUS BENZODIAZEPINE RECEPTOR LIGANDS IN IDIOPATHIC RECURRING STUPOR
    ROTHSTEIN, JD
    GUIDOTTI, A
    TINUPER, P
    CORTELLI, P
    AVONI, P
    PLAZZI, G
    LUGARESI, E
    SCHOCH, P
    MONTAGNA, P
    LANCET, 1992, 340 (8826): : 1002 - 1004
  • [23] ENDOGENOUS LIGANDS AND MODULATORS OF THE DIGITALIS RECEPTOR - SOME CANDIDATES
    KIM, RSS
    LABELLA, FS
    PHARMACOLOGY & THERAPEUTICS, 1981, 14 (03) : 391 - 409
  • [24] Tethered ligands reveal glutamate receptor desensitization depends on subunit occupancy
    Reiner, Andreas
    Isacoff, Ehud Y.
    NATURE CHEMICAL BIOLOGY, 2014, 10 (04) : 273 - +
  • [25] Tethered ligands reveal glutamate receptor desensitization depends on subunit occupancy
    Reiner A.
    Isacoff E.Y.
    Nature Chemical Biology, 2014, 10 (4) : 273 - 280
  • [26] Neuropeptide receptor ligands as drugs for psychiatric diseases
    Laffman-Johnson, Elise
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2012, 92 (03) : 272 - 272
  • [27] Chapter 26. PET ligands for assessing receptor occupancy in vivo
    Burns, HD
    Hamill, TG
    Eng, WS
    Hargreaves, R
    ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 36, 2001, 36 : 267 - 276
  • [28] IDENTIFICATION OF DYNORPHINS AS ENDOGENOUS LIGANDS FOR AN OPIOID RECEPTOR-LIKE ORPHAN RECEPTOR
    ZHANG, SW
    YU, L
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (39) : 22772 - 22776
  • [29] DISPLACEMENT BY ANIONIC DRUGS OF ENDOGENOUS LIGANDS BOUND TO ALBUMIN IN UREMIC SERUM
    MABUCHI, H
    NAKAHASHI, H
    THERAPEUTIC DRUG MONITORING, 1988, 10 (03) : 261 - 264
  • [30] Identification of dynorphins as endogenous ligands for an opioid receptor-like orphan receptor
    1600, American Society for Biochemistry and Molecular Biology Inc., Bethesda, United States (270):
12345