DRUGS AND ENDOGENOUS LIGANDS COMPETE FOR RECEPTOR OCCUPANCY

被引：5
|
作者：
COLBURN, WA
机构：
[1] Harris Laboratories, Inc., Clinical Development Division, Phoenix, AZ 85040
来源：
JOURNAL OF CLINICAL PHARMACOLOGY | 1994年 / 34卷 / 12期
关键词：
D O I：
10.1002/j.1552-4604.1994.tb04724.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Dietary and endogenous ligands compete with drugs for receptor occupancy and therefore should be considered during therapeutic interventions and during pharmacokinetic/ pharmacodynamic modeling. When disease is the result of an overabundance of these natural ligands, antibodies and/or their Fab fragments may be useful as therapeutic agents to reverse the effects of the natural ligands.
引用
收藏
页码：1148 / 1152
页数：5
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