HYPOGLYCEMIC ACTIVITY OF NELUMBO-NUCIFERA GAERTN (FAM NYMPHAEACEAE) RHIZOME (METHANOLIC EXTRACT) IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

被引：27

作者：

MUKHERJEE, PK ^{[1
]}

PAL, SK ^{[1
]}

SAHA, K ^{[1
]}

SAHA, BP ^{[1
]}

机构：

[1] JADAVPUR UNIV,DEPT PHARMACEUT TECHNOL,CALCUTTA 700032,W BENGAL,INDIA

来源：

PHYTOTHERAPY RESEARCH | 1995年 / 9卷 / 07期

关键词：

NELUMBO NUCIFERA; RHIZOMES; HYPOGLYCEMIC ACTIVITY; STREPTOZOTOCIN-DIABETIC RATS;

D O I：

10.1002/ptr.2650090712

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The hypoglycaemic effect of the rhizome extract of Nelumbo nucifera was studied in streptozotocin-induced diabetic rats. A methanol extract of the plant obtained by soxhlet extraction from finely pulverized rhizomes was used, The LD(50) Of the extract was found to be 2 g/kg, The extract (300 mg/kg and 600 mg/kg, orally) caused a reduction of blood glucose levels in streptozotocin-induced diabetic rats by 53% (p< 0.001) and 55% (p < 0.001) respectively at the end of 12 h, The results of this study indicate that the methanol extract of the rhizome possesses favourable hypoglycaemic activity in hyperglycaemic animals taking chlorpropamide as a standard.

引用

页码：522 / 524

页数：3

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