BETA-AMYLOID PROTEIN IN ALZHEIMERS-DISEASE

被引：5
|
作者：
NALBANTOGLU, J
机构：
[1] MCGILL UNIV,MCGILL CTR STUDIES AGING,DEPT MED,MONTREAL H3A 2T5,QUEBEC,CANADA
[2] MCGILL UNIV,MCGILL CTR STUDIES AGING,DEPT NEUROL & NEUROSURG,MONTREAL H3A 2T5,QUEBEC,CANADA
来源：
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1991年 / 18卷 / 03期
关键词：
D O I：
10.1017/S0317167100032595
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Beta-amyloid protein, a 42-43 amino acid polypeptide, accumulates abnormally in senile plaques and the cerebral vasculature in Alzheimer's disease. This polypeptide is derived from a membrane-associated precursor which has several isoforms expressed in many tissues. The precursor protein is processed constitutively within the beta-amyloid domain, leading to the release of the large N-terminal portion into the extracellular medium. beta-amyloid protein may be toxic to certain neuronal cell types and its early deposition may be an important event in the pathogenesis of Alzheimer's disease.
引用
收藏
页码：424 / 427
页数：4
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