AFFINITIES OF SM-7338 FOR PENICILLIN-BINDING PROTEINS AND ITS RELEASE FROM THESE PROTEINS IN STAPHYLOCOCCUS-AUREUS

被引：26
|
作者：
SUMITA, Y
FUKASAWA, M
OKUDA, T
机构：
[1] Research Laboratories, Sumitomo Pharmaceuticals Co., Konohana-ku, Osaka 554, 3-1-98, Kasugade-naka
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 03期
关键词：
D O I：
10.1128/AAC.34.3.484
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
SM-7338, a carbapenem antibiotic, had high affinities for penicillin-binding proteins (PBPs) 1, 2, and 4 of Staphylococcus aureus but not for PBP 3 when a competition assay with [14C]benzylpenicillin was used. However, binding of [14C]SM-7338 was saturated for PBP 3 at a concentration of 1 μg/ml. These results were due to the rapid release of SM-7338 from PBP 3-SM-7338 complexes with a half-life of 2 min.
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页码：484 / 486
页数：3
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