Effect of Statins on the Mortality of Bacteremic Patients: A Systematic Review and Meta-analysis of Clinical Trials

被引：9

作者：

Shrestha, Pragya ^{[1
]}

Poudel, Dilli R. ^{[2
]}

Pathak, Ranjan ^{[2
]}

Ghimire, Sushil ^{[2
]}

Dhital, Rashmi ^{[3
]}

Aryal, Madan R. ^{[2
]}

Mahmood, Maryam ^{[2
]}

Karmacharya, Paras ^{[2
]}

机构：

[1] Nanjing Med Univ, Dept Internal Med, Nanjing, Jiangsu, Peoples R China

[2] Reading Hlth Syst, Dept Internal Med, W Reading, PA 19611 USA

[3] Univ Coll Med Sci, Dept Internal Med, Bhairahawa, Nepal

来源：

NORTH AMERICAN JOURNAL OF MEDICAL SCIENCES | 2016年 / 8卷 / 06期

关键词：

Bacteremia; infection; inflammation; mortality;

D O I：

10.4103/1947-2714.185034

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Statins modify inflammatory cell signaling during the immune response to infection. This has been considered as a pleotropic effect. Effects of statins in inflammatory conditions such as bacteremia have been found to be controversial. Aims: We examined the effect of statins on the mortality of bacteremia patients. Materials and Methods: Major databases were searched for the pertinent clinical trials. Results: Six cohort studies comprising 7553 patients were included. Hospital mortality was lower (15.36% vs 22.28%) in patients on statin. Conclusions: There may be a potential role of statins in similar inflammatory and infective conditions.

引用

页码：250 / +

页数：2

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