Moving ahead on harnessing synthetic lethality to fight cancer

被引：1
|
作者：
Jerby-Arnon, Livnat [1 ]
Ruppin, Eytan [1 ,2 ]
机构：
[1] Tel Aviv Univ, Blavatnik Sch Comp Sci, Tel Aviv, Israel
[2] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2015年 / 2卷 / 02期
关键词：
synthetic lethality; genetic interactions; cancer genomics; precision medicine;
D O I：
10.4161/23723556.2014.977150
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have recently developed a data-mining pipeline that comprehensively identifies cancer unique susceptibilities, following the concept of Synthetic Lethality (SL). The approach enables, for the first time, to identify and harness genome-scale SL-networks to accurately predict gene essentiality, drug response, and clinical prognosis in cancer.
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页数：3
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