PHARMACOKINETICS OF FLUVOXAMINE MALEATE AFTER INCREASING SINGLE ORAL DOSES IN HEALTHY-SUBJECTS

被引：23
|
作者：
DEVRIES, MH
VANHARTEN, J
VANBEMMEL, P
RAGHOEBAR, M
机构：
[1] Clinical R&D Solvay, Weesp, 1380 DA
来源：
BIOPHARMACEUTICS & DRUG DISPOSITION | 1993年 / 14卷 / 04期
关键词：
FLUVOXAMINE; PHARMACOKINETICS; DOSE-DEPENDENCY; HUMAN;
D O I：
10.1002/bdd.2510140403
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The pharmacokinetics of fluvoxamine after single oral administration of 25, 50, and 100 mg fluvoxamine maleate was studied in a three-way cross-over study in 12 healthy male subjects. Fluvoxamine was administered orally in a solution. For dose-proportionality, AUC, and C(max)-dose relationships were evaluated by linear regression. Plasma concentrations increased in a linear dose-dependent manner in the dose range between 25 and 100 mg; t1/2 and T(max) showed no significant differences among treatments. Fluvoxamine was well tolerated.
引用
收藏
页码：291 / 296
页数：6
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