PHOTOSENSITIZED FORMATION OF 8-HYDROXY-2'-DEOXYGUANOSINE IN SALMON TESTES DNA BY FUROCOUMARIN HYDROPEROXIDES - A NOVEL, INTERCALATING PHOTO-FENTON REAGENT FOR OXIDATIVE DNA-DAMAGE

被引：40
|
作者：
ADAM, W
CADET, J
DALLACQUA, F
EPE, B
RAMAIAH, D
SAHAMOLLER, CR
机构：
[1] CEA,DEPT RECH FONDAMENTALE MAT CONDENSEE,SESAM LES ACIDES NUCL,GRENOBLE,FRANCE
[2] UNIV PADUA,DEPT PHARMACEUT SCI,PADUA,ITALY
[3] UNIV WURZBURG,INST PHARMAKOL & TOXIKOL,W-8700 WURZBURG,GERMANY
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 01期
关键词：
DNA OXIDATION; FUROCOUMARINS; HYDROPEROXIDES; 8-HYDROXY-2'-DEOXYGUANOSINE; HYDROXYL RADICALS;
D O I：
10.1002/anie.199501071
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Furocoumarin hydroperoxides such as 1 are novel photochemical sources of hydroxyl radicals; in salmon testes DNA they form the mutagenic oxidation product 8‐hydroxy‐2′‐deoxyguanosine 2 in up to 1.8% yield on UVA irradiation (λ = 350 nm). (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany
引用
收藏
页码：107 / 110
页数：4
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