PHOTOSENSITIZED FORMATION OF 8-HYDROXY-2'-DEOXYGUANOSINE IN SALMON TESTES DNA BY FUROCOUMARIN HYDROPEROXIDES - A NOVEL, INTERCALATING PHOTO-FENTON REAGENT FOR OXIDATIVE DNA-DAMAGE

被引：40
|
作者：
ADAM, W
CADET, J
DALLACQUA, F
EPE, B
RAMAIAH, D
SAHAMOLLER, CR
机构：
[1] CEA,DEPT RECH FONDAMENTALE MAT CONDENSEE,SESAM LES ACIDES NUCL,GRENOBLE,FRANCE
[2] UNIV PADUA,DEPT PHARMACEUT SCI,PADUA,ITALY
[3] UNIV WURZBURG,INST PHARMAKOL & TOXIKOL,W-8700 WURZBURG,GERMANY
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 01期
关键词：
DNA OXIDATION; FUROCOUMARINS; HYDROPEROXIDES; 8-HYDROXY-2'-DEOXYGUANOSINE; HYDROXYL RADICALS;
D O I：
10.1002/anie.199501071
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Furocoumarin hydroperoxides such as 1 are novel photochemical sources of hydroxyl radicals; in salmon testes DNA they form the mutagenic oxidation product 8‐hydroxy‐2′‐deoxyguanosine 2 in up to 1.8% yield on UVA irradiation (λ = 350 nm). (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany
引用
收藏
页码：107 / 110
页数：4
相关论文
共 50 条
  • [1] Photochemistry and photobiology of furocoumarin hydroperoxides derived from imperatorin: Novel intercalating photo-Fenton reagents for oxidative DNA modification by hydroxyl radicals
    Adam, W
    Berger, M
    Cadet, J
    DallAcqua, F
    Epe, B
    Frank, S
    Ramaiah, D
    Raoul, S
    SahaMoller, CR
    Vedaldi, D
    PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1996, 63 (06) : 768 - 778
  • [2] THE ROLE OF 8-HYDROXY-2'-DEOXYGUANOSINE IN RIFAMYCIN-INDUCED DNA-DAMAGE
    MUNIZ, P
    VALLS, V
    PEREZBROSETA, C
    IRADI, A
    CLIMENT, JV
    OLIVA, MR
    SAEZ, GT
    FREE RADICAL BIOLOGY AND MEDICINE, 1995, 18 (04) : 747 - 755
  • [3] LEVELS OF OXIDATIVE DNA-DAMAGE PRODUCT 8-HYDROXY-2'-DEOXYGUANOSINE IN HUMAN SERUM INCREASE WITH AGE
    RATTAN, SIS
    SIBOSKA, GE
    WIKMAR, FP
    CLARK, BFC
    WOOLLEY, P
    MEDICAL SCIENCE RESEARCH, 1995, 23 (07): : 469 - 470
  • [4] ASSAYS FOR 8-HYDROXY-2'-DEOXYGUANOSINE - A BIOMARKER OF INVIVO OXIDATIVE DNA DAMAGE
    SHIGENAGA, MK
    AMES, BN
    FREE RADICAL BIOLOGY AND MEDICINE, 1991, 10 (3-4) : 211 - 216
  • [5] Studies of 8-hydroxy-2′-deoxyguanosine:: A biomarker for oxidative DNA damage in vivo?
    Marczynski, B
    Hölzer, J
    Wilhelm, M
    BIOLOGICAL MONITORING: PROSPECTD IN OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 2002, : 68 - 77
  • [6] 8-HYDROXY-2'-DEOXYGUANOSINE FORMATION AND DNA-DAMAGE INDUCED BY SULFUR-TRIOXIDE ANION-RADICALS
    SHI, XL
    MAO, Y
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 205 (01) : 141 - 147
  • [7] PHOTOSENSITIZED FORMATION OF 8-HYDROXY-2'-DEOXYGUANOSINE AND DNA STRAND BREAKAGE BY A CATIONIC MESOSUBSTITUTED PORPHYRIN
    NICOTERA, TM
    MUNSON, BR
    FIEL, RJ
    PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1994, 60 (04) : 295 - 300
  • [8] OXIDATIVE DAMAGE TO DNA DURING AGING - 8-HYDROXY-2'-DEOXYGUANOSINE IN RAT ORGAN DNA AND URINE
    FRAGA, CG
    SHIGENAGA, MK
    PARK, JW
    DEGAN, P
    AMES, BN
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (12) : 4533 - 4537
  • [9] URINARY 8-HYDROXY-2'-DEOXYGUANOSINE AS A BIOLOGICAL MARKER OF INVIVO OXIDATIVE DNA DAMAGE
    SHIGENAGA, MK
    GIMENO, CJ
    AMES, BN
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (24) : 9697 - 9701
  • [10] 8-Hydroxy-2′-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures
    Pilger, A.
    Ruediger, H. W.
    INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 2006, 80 (01) : 1 - 15
12345