EVALUATION OF SYNERGISM OR ANTAGONISM FOR THE COMBINED ACTION OF ANTIVIRAL AGENTS

被引：80
|
作者：
SUHNEL, J
机构：
[1] Central Institute of Microbiology and Experimental Therapy, Academy of Sciences, the G.D.R., Jena
来源：
ANTIVIRAL RESEARCH | 1990年 / 13卷 / 01期
关键词：
Antagonism; Antiviral combination experiment; Isobole method; Mathematical modeling; Synergism;
D O I：
10.1016/0166-3542(90)90042-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The criteria used for the evaluation of synergism or antagonism for the combined action of antiviral agents are critically reviewed. The isobole method is the only generally applicable approach which does not require any assumptions about the shape of dose-response curves. A microcomputer-based isobole method is proposed which constructs response surfaces and a complete set of isoboles in the dose range under study from a relatively small number of experiments. The objective of this work is to take a step towards standardization of definitions, terminology, and methods for the evaluation of synergism or antagonism in antiviral drug combination experiments. © 1990.
引用
收藏
页码：23 / 40
页数：18
相关论文
共 50 条
  • [41] In vitro demonstration of synergism with pixantrone combined with targeted agents in lymphomas
    Tarantelli, Chiara
    Gaudio, Eugenio
    Cascione, Luciano
    Stathis, Anastasios
    Zucca, Emanuele
    Bertoni, Francesco
    BRITISH JOURNAL OF HAEMATOLOGY, 2019, 186 (01) : 149 - 152
  • [42] ANTIVIRAL AGENTS - SYNTHESIS OF FURYLPYRIMIDINONES AND EVALUATION OF THEIR CYTOSTATIC AND ANTIVIRAL ACTIVITY
    BOTTA, M
    DEANGELIS, F
    CORELLI, F
    MENICHINCHERI, M
    NICOLETTI, R
    MARONGIU, ME
    PANI, A
    LACOLLA, P
    ARCHIV DER PHARMAZIE, 1991, 324 (04) : 203 - 207
  • [43] STUDIES ON ANTIBIOTIC SYNERGISM AND ANTAGONISM - THE INTERFERENCE OF AUREOMYCIN OR TERRAMYCIN WITH THE ACTION OF PENICILLIN IN INFECTIONS IN MICE
    SPECK, RS
    JAWETZ, E
    GUNNISON, JB
    ARCHIVES OF INTERNAL MEDICINE, 1951, 88 (02) : 168 - 174
  • [44] Synergism and antagonism of phosphorus-containing epoxy resin combined with different metal hydroxides
    Liao, Honghui
    Liu, Yuansen
    Jiang, Jun
    Li, Jiang
    Liu, Yuan
    JOURNAL OF FIRE SCIENCES, 2016, 34 (01) : 3 - 12
  • [45] Complex interactions of lovastatin with 10 chemotherapeutic drugs: a rigorous evaluation of synergism and antagonism
    Gilman, Kaitlyn A. Khandelwal
    Han, Seungmin
    Won, Young-Wook
    Putnam, Charles W.
    BMC CANCER, 2021, 21 (01)
  • [46] SOME ASPECTS OF THE NOTIONS ADDITIVITY, SYNERGISM AND ANTAGONISM IN THE SIMULTANEOUS ACTIVITY OF 2 ANTIBACTERIAL AGENTS INVITRO
    VOORSPUIJ, AJZ
    NASS, CAG
    ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE, 1957, 109 (1-2): : 211 - 228
  • [47] Complex interactions of lovastatin with 10 chemotherapeutic drugs: a rigorous evaluation of synergism and antagonism
    Kaitlyn A. Khandelwal Gilman
    Seungmin Han
    Young-Wook Won
    Charles W. Putnam
    BMC Cancer, 21
  • [48] Unique synergism or antagonism of combinations of chemotherapeutic and hormonal agents in human prostate cancer cell lines
    Kreis, W
    Budman, DR
    Calabro, A
    BRITISH JOURNAL OF UROLOGY, 1997, 79 (02): : 196 - 202
  • [49] Relevance of synergism and antagonism phenomena detected among antimicrobial agents with automated systems for antibiogram reading
    Navarro, Ferran
    Mirelis, Beatriz
    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2007, 25 (02): : 75 - 76
  • [50] ANTIBIOTIC SYNERGISM AND ANTAGONISM - AN ASSESSMENT OF THE PROBLEM
    JAWETZ, E
    GUNNISON, JB
    PHARMACOLOGICAL REVIEWS, 1953, 5 (02) : 175 - 192
12345