PHARMACOKINETICS OF DIPHEMANIL METHYLSULFATE IN HEALTHY-SUBJECTS

被引：0
|
作者：
VIDAL, AM [1 ]
REY, E [1 ]
PONS, G [1 ]
PELLO, JY [1 ]
DATHIS, P [1 ]
OLIVE, G [1 ]
机构：
[1] HOP ST VINCENT DE PAUL,DEPT PHARMACOL PERINATALE & PEDIAT,82 AVE DENFERT ROCHEREAU,F-75674 PARIS 14,FRANCE
来源：
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 42卷 / 06期
关键词：
DIPHEMANIL METHYSULPHATE; PHARMACOKINETICS; HEALTHY SUBJECTS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The pharmacokinetic parameters of oral diphemanil methylsulphate have been evaluated in six healthy male volunteers. Absorption of the drug was slow (t(max) = 2 to 4 h), the mean half-life was 8.35 h, and the amount of -the drug recovered in urine within 48 h ranged from 0.6 to 7.4 % of the administered dose. The results suggest low bioavailability, assuming that the drug is poorly metabolized.
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页码：689 / 692
页数：4
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