Evaluation of acute toxicity and intestinal transit time of Croton tiglium L. seeds

被引:0
|
作者
Vekariya, Shweta [1 ]
Taviad, Krushnkumar [2 ]
Ranpariya, Nidhi [3 ]
Nariya, Mukesh [3 ]
Acharya, R. N. [4 ]
机构
[1] Gujarat Ayurved Univ, Dept Dravyaguna, Jamnagar 361008, Gujarat, India
[2] Gujarat Ayurved Univ, Dept Rasa Shastra & Bhaishajya Kalpana, Jamnagar 361008, Gujarat, India
[3] Gujarat Ayurved Univ, Dept Pharmacol, Jamnagar 361008, Gujarat, India
[4] Gujarat Ayurved Univ, Dept Dravyaguna, Inst Post Grad Teaching & Res Ayurveda, Jamnagar 361008, Gujarat, India
来源
INDIAN JOURNAL OF NATURAL PRODUCTS AND RESOURCES | 2018年 / 9卷 / 04期
关键词
Acute toxicity; Croton tiglium; Intestinal transit; Jayapala; Shodhana;
D O I
暂无
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The seeds of Jayapala (Croton tiglium L.) (Euphorbiaceae) is classified under Upavisha in classical texts of Ayurveda known for its purgative action and is being used in the management of several disorders. Ayurvedic Pharmacopoeia of India recommends its Shodhana prior to its internal administration. The present study was planned with an aim to evaluate the acute toxicity of raw and Shodhita seeds of Croton tiglium L. and intestinal transit time of Shodhita seeds on experimental animals. Acute oral toxicity study for Raw Jayapala (RJ) and Shodhita Jayapala (SJ) seed sample were carried out following OECD guidelines. Rats were administered a single dose of 2000 mg/kg orally and then observed individually for the first 30 mins, then over a period of every 2 hours for 24 hours and at least once daily for 14 days. General behaviour, adverse effects and mortality were observed throughout the experimental period. Intestinal transit time in mice was carried out at the lower dose of 2.54 mg/kg and the higher dose of 7.61 mg/kg by adopting Kaolin expulsion test and latency of the onset of kaolin expulsion in faecal matter. The results showed that the raw Jayapala produced mortality in a single oral dose of 2000 mg/kg while Shodhita Jayapala did not Jayapala produce any mortality and toxicity except behavioural changes and diarrhoea at the same dose level. In kaolin expulsion test, Shodhita Jayapala produced marked increase in intestinal motility in mice among which higher dose of the drug was found better which was proved by fast clearance of kaolin in faecal pellet in comparison to control group. Oral acute toxicity study suggests that Shodhana (processing/purifying) process must be advocated for use of Jayapala to eliminate the untoward effects. Further, Shodhita (processed) Jayapala seeds have markedly increased the intestinal motility confirms the Virechana (purgation) karma of drug in mice.
引用
收藏
页码:331 / 335
页数:5
相关论文
共 50 条
  • [21] Subchronic toxicity evaluation of ethanol extract of Cassia tora L. seeds in rats
    Lee, Mu-Jin
    Nho, Jong-Hyun
    Yang, Beo-Deul
    Park, Ho
    Lee, Hyun-Joo
    Lee, Ki-Ho
    Jang, Ji-Hun
    Jung, Ho-Kyung
    Kim, Sun-Ra
    Cho, Hyun-Woo
    Park, Hae-Sung
    Lim, Je-Oh
    Kim, Jong-Choon
    REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2019, 109
  • [22] Evaluation of Acute toxicity of Lambda Cyhalothrin in Mus musculus L.
    Tomar, Monika
    Kumar, Ajay
    Kataria, Sudhir Kumar
    INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, 2015, 53 (08) : 551 - 555
  • [23] EVALUATION OF THE ACUTE AND SUBCHRONIC TOXICITY OF Aster tataricus L. F.
    Peng, Wen-jing
    Xin, Rui-hua
    Luo, Yong-jiang
    Liang, Ge
    Ren, Li-hua
    Liu, Yan
    Wang, Gui-bo
    Zheng, Ji-fang
    AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES, 2016, 13 (06) : 38 - 53
  • [24] In vivo acute toxicity, antidiabetic and antiulcer activities of polysaccharide from Linum usitatissimum L. seeds
    Mohanta, Bulu
    Sen, Dhrubo Jyoti
    Mahanti, Beduin
    Nayak, Amit Kumar
    FOOD BIOSCIENCE, 2023, 56
  • [25] Evaluation of Acute Toxicity of the Alkaloids of Peganum harmala L Seeds in Albino Wistar Female Rats
    Mahdeb, N.
    Bettihi, S.
    Ghedjati, N.
    Bouzidi, A.
    ADVANCES IN PHARMACOLOGY AND PHARMACY, 2020, 8 (02) : 24 - 30
  • [26] Acute and sub-acute toxicity evaluation of Merremia tridentata (L.) stem extract on mice
    Pham, Em Canh
    Van, Lenh Vo
    Nguyen, Cuong Viet
    Duong, Ngoc Thoi Nguyen
    Thi, Tuong Vi Le
    Truong, Tuyen Ngoc
    TOXICON, 2023, 227
  • [27] ACUTE TOXICITY OF SEEDS OF THE SAPODILLA (ACHRAS-SAPOTA L)
    SINGH, PDA
    SIMON, OR
    WEST, ME
    TOXICON, 1984, 22 (01) : 145 - 147
  • [28] Germination of Croton urucurana L. seeds exposed to different storage temperatures and pre-germinative treatments
    Scalon, Silvana P. Q.
    Mussury, Rosilda M.
    Lima, Andrea A.
    ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS, 2012, 84 (01): : 191 - 200
  • [29] Time of harvest and storability of Crotalaria juncea L. seeds
    de Araujo, Alisson Vinicius
    Araujo, Eduardo Fontes
    Ribeiro Amaro, Hugo Tiago
    Silva Santos, Ricardo Henrique
    Cecon, Paulo Roberto
    REVISTA CIENCIA AGRONOMICA, 2018, 49 (01): : 103 - 111
  • [30] Evaluation of acute and subacute toxicity of Vernonia cinerea (L.) Less using mice model
    Johnson, Jimsy
    Varghese, Leyon
    INDIAN JOURNAL OF NATURAL PRODUCTS AND RESOURCES, 2023, 14 (02): : 270 - 277