INHIBITION OF RABBIT BRAIN PROLYL ENDOPEPTIDASE BY N-BENZYLOXYCARBONYL-PROLYL-PROLINAL, A TRANSITION-STATE ALDEHYDE INHIBITOR

被引:152
|
作者
WILK, S
ORLOWSKI, M
机构
关键词
D O I
10.1111/j.1471-4159.1983.tb11815.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:69 / 75
页数:7
相关论文
共 14 条
  • [1] PROLYL ENDOPEPTIDASE - INHIBITION INVIVO BY "N-BENZYLOXYCARBONYL-PROLYL-PROLINAL
    FRIEDMAN, TC
    ORLOWSKI, M
    WILK, S
    JOURNAL OF NEUROCHEMISTRY, 1984, 42 (01) : 237 - 241
  • [2] INHIBITION OF PROLYL ENDOPEPTIDASE BY BENZYLOXYCARBONYL-PROLYL-PROLINAL INVIVO
    FRIEDMAN, TC
    ORLOWSKI, M
    WILK, S
    FEDERATION PROCEEDINGS, 1983, 42 (03) : 357 - 357
  • [3] SLOW TIGHT-BINDING INHIBITION OF PROLYL ENDOPEPTIDASE BY BENZYLOXYCARBONYL-PROLYL-PROLINAL
    BAKKER, AV
    JUNG, S
    SPENCER, RW
    VINICK, FJ
    FARACI, WS
    BIOCHEMICAL JOURNAL, 1990, 271 (02) : 559 - 562
  • [4] Identification and initial characterisation of a N-benzyloxycarbonyl-prolyl-prolinal (Z-Pro-prolinal)-insensitive 7-(N-benzyloxycarbonyl-glycyl-prolyl-amido)-4-methylcoumarin (Z-Gly-Pro-NH-Mec)-hydrolysing peptidase in bovine serum
    Cunningham, DF
    OConnor, B
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 244 (03): : 900 - 903
  • [5] Prolyl endopeptidase inhibitor prevents changes in the monoaminergic systems in the brain of rats with anxiety-depressive state
    Krupina, N.
    Khlebnikova, N.
    Kushnareva, E.
    Kudrin, V.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2014, 24 : S254 - S255
  • [6] Effect of Imipramine and Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Activity of Proline-Specific Peptidases in the Brain of Rats with Experimental Anxious-Depressive Syndrome
    Khlebnikova, N. N.
    Krupina, N. A.
    Kushnareva, E. Yu.
    Zolotov, N. N.
    Kryzhanovskii, G. N.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2012, 152 (04) : 409 - 412
  • [7] Effect of Imipramine and Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Activity of Proline-Specific Peptidases in the Brain of Rats with Experimental Anxious-Depressive Syndrome
    N. N. Khlebnikova
    N. A. Krupina
    E. Yu. Kushnareva
    N. N. Zolotov
    G. N. Kryzhanovskii
    Bulletin of Experimental Biology and Medicine, 2012, 152 : 409 - 412
  • [8] Effect of Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Activity of Proline-Specific Peptidases in Brain Structures of Rats with Experimental MPTP-Induced Depressive Syndrome
    Khlebnikova, N. N.
    Krupina, N. A.
    Bogdanova, N. G.
    Zolotov, N. N.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2013, 155 (06) : 711 - 714
  • [9] Effect of Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Activity of Proline-Specific Peptidases in Brain Structures of Rats with Experimental MPTP-Induced Depressive Syndrome
    N. N. Khlebnikova
    N. A. Krupina
    N. G. Bogdanova
    N. N. Zolotov
    Bulletin of Experimental Biology and Medicine, 2013, 155 : 711 - 714
  • [10] Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine, a Prolyl Endopeptidase Inhibitor, Modulates Depression-Like Behavior of Rats in Forced Swimming Test and Activities of Proline-Specific Peptidases in the Brain Structures
    Krupina, N. A.
    Bogdanova, N. G.
    Khlebnikova, N. N.
    Zolotov, N. N.
    Kryzhanovskii, G. N.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2013, 154 (05) : 606 - 609