Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine, a Prolyl Endopeptidase Inhibitor, Modulates Depression-Like Behavior of Rats in Forced Swimming Test and Activities of Proline-Specific Peptidases in the Brain Structures

被引：8

作者：

Krupina, N. A. ^{[1
]}

Bogdanova, N. G. ^{[1
]}

Khlebnikova, N. N. ^{[1
]}

Zolotov, N. N. ^{[2
]}

Kryzhanovskii, G. N. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Lab Nervous Syst Gen Pathol, Moscow 109801, Russia

[2] Russian Acad Med Sci, VV Zakusov Inst Pharmacol, Lab Psychopharmacol, Moscow 109801, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2013年 / 154卷 / 05期

关键词：

behavioral despair; prolyl endopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine; prolyl endopeptidase and dipeptidylpeptidase IV; rat brain structures; IV; ANXIETY; IMMUNOTHERAPY; ALPHA;

D O I：

10.1007/s10517-013-2010-y

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

High activities of prolyl endopeptidase and dipeptidylpeptidase IV in the striatum and of prolyl endopeptidase in the frontal cortex were recorded in rats with stress-induced depressionlike state (behavioral despair) developed in the Porsolt forced swimming test. Acute injection of benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine (prolyl endopeptidase noncompetitive synthetic inhibitor) in a dose of 1 mg/kg prevented the development of behavioral despair and the increase of prolyl endopeptidase and dipeptidylpeptidase IV activities in the brain structures. In a dose of 2 mg/kg prolyl endopeptidase inhibitor did not modify the development of behavioral despair, but prevented the increase of prolyl endopeptidase and dipeptidylpeptidase IV activities in the striatum.

引用

页码：606 / 609

页数：4

共 8 条

[1] Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine, a Prolyl Endopeptidase Inhibitor, Modulates Depression-Like Behavior of Rats in Forced Swimming Test and Activities of Proline-Specific Peptidases in the Brain Structures
N. A. Krupina
N. G. Bogdanova
N. N. Khlebnikova
N. N. Zolotov
G. N. Kryzhanovskii
Bulletin of Experimental Biology and Medicine, 2013, 154 : 606 - 609
[2] Effect of Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Activity of Proline-Specific Peptidases in Brain Structures of Rats with Experimental MPTP-Induced Depressive Syndrome
N. N. Khlebnikova
N. A. Krupina
N. G. Bogdanova
N. N. Zolotov
Bulletin of Experimental Biology and Medicine, 2013, 155 : 711 - 714
[3] Effect of Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Activity of Proline-Specific Peptidases in Brain Structures of Rats with Experimental MPTP-Induced Depressive Syndrome
Khlebnikova, N. N.
Krupina, N. A.
Bogdanova, N. G.
Zolotov, N. N.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2013, 155 (06) : 711 - 714
[4] Effect of Imipramine and Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Activity of Proline-Specific Peptidases in the Brain of Rats with Experimental Anxious-Depressive Syndrome
Khlebnikova, N. N.
Krupina, N. A.
Kushnareva, E. Yu.
Zolotov, N. N.
Kryzhanovskii, G. N.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2012, 152 (04) : 409 - 412
[5] Effect of Imipramine and Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Activity of Proline-Specific Peptidases in the Brain of Rats with Experimental Anxious-Depressive Syndrome
N. N. Khlebnikova
N. A. Krupina
E. Yu. Kushnareva
N. N. Zolotov
G. N. Kryzhanovskii
Bulletin of Experimental Biology and Medicine, 2012, 152 : 409 - 412
[6] Effects of synthetic inhibitor of prolyl endopeptidase benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine in Porsolt forced swim test
Krupina, N. A.
Bogdanova, N. G.
Khlebnikova, N. N.
Zolotov, N. N.
Orlova, I. N.
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2011, 21 : S415 - S416
[7] Effect of Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on the Course of Experimental Depressive Syndrome in Rats
N. N. Khlebnikova
N. A. Krupina
N. G. Bogdanova
I. N. Orlova
N. N. Zoloto
Bulletin of Experimental Biology and Medicine, 2013, 155 : 190 - 193
[8] Effect of Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on the Course of Experimental Depressive Syndrome in Rats
Khlebnikova, N. N.
Krupina, N. A.
Bogdanova, N. G.
Orlova, I. N.
Zolotov, N. N.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2013, 155 (02) : 190 - 193

← 1 →