Effect of Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on the Course of Experimental Depressive Syndrome in Rats

被引：3
|
作者：
Khlebnikova, N. N. [1 ]
Krupina, N. A. [1 ]
Bogdanova, N. G. [1 ]
Orlova, I. N. [1 ]
Zolotov, N. N. [2 ]
机构：
[1] Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Lab Gen Pathol Nervous Syst, Moscow, Russia
[2] Russian Acad Med Sci, Lab Psychopharmacol, VV Zakusov Inst Pharmacol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2013年 / 155卷 / 02期
关键词：
experimental depressive syndrome; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin; inhibitor of prolyl endopeptidases; benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine; DIPEPTIDYL PEPTIDASE-IV; PROLINE-SPECIFIC PEPTIDASES; EARLY POSTNATAL-PERIOD; BRAIN STRUCTURES; MPTP; STATE; MODEL;
D O I：
10.1007/s10517-013-2109-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of noncompetitive prolyl endopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine were studied in rats with the experimental dopamine deficiency-dependent depressive syndrome induced by systemic injections of a pre-neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin for 14 days. The inhibitor (3.0 mg/kg, i.p., 30 min before pre-neurotoxin injection on days 8-14) alleviated depression symptoms and promoted normalization of behavioral activity after drug withdrawal. The obtained data reflected therapeutic antidepressant properties of inhibitor for prolyl endopeptidase benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine.
引用
收藏
页码：190 / 193
页数：4
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