ANTISPASMODIC AND ANTHELMINTIC ACTIVITY OF NYCTANTHES ARBORTRISTIS LINN

被引：9
|
作者：
Das, Sanjita [1 ]
Sasmal, Dinakar [2 ]
Basu, Saumya Priya [1 ]
机构：
[1] Noida Inst Engn & Technol, Dept Pharmaceut Technol, Greater Noida, UP, India
[2] Birla Inst Technol, Dept Pharmaceut Sci, Ranchi, Jharkhand, India
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2010年 / 1卷 / 02期
关键词：
Nyctanthes arbortristis Linn; antispasmodic; Pheretima posthuma; anthelmintic activity; acetylcholine;
D O I：
10.13040/IJPSR.0975-8232.1(2).51-55
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Antispasmodic activity of the ethanolic extracts of different parts of Nyctanthes arbortristis Linn. was estimated using guinea pig ileum preparation against acetylcholine. Anthelmintic activity was tested following the method described by Kailashraj and Kurup, using earthworm (Pheretima posthuma). The extracts exhibited antispasmodic activity, which was less than that of piperazine citrate. The ethanolic extracts were found to have concentration-dependent paralytic activity, whereas its seeds and flowers showed lethal effect on the worms. It was also observed that the paralytic and lethal effects of respective ethanolic extracts were potentiated by the presence of atropine. It reveals that the anthelmintic activity of the extracts is due to the inhibition of motility by relaxing and depressing responsiveness to contractile action of acetylcholine.
引用
收藏
页码：51 / 55
页数：5
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