IMMUNE-RESPONSE OF MICE INFECTED WITH RECOMBINANT VACCINIA VIRUSES CARRYING THE HIV GAG GENE

被引:2
|
作者
SUGATA, F [1 ]
AOKI, N [1 ]
SHIODA, T [1 ]
HAYASHI, T [1 ]
SHIMADA, K [1 ]
MITAMURA, K [1 ]
SHIBUTA, H [1 ]
机构
[1] UNIV TOKYO,INST MED SCI,DEPT VIRAL INFECT,MINATO KU,TOKYO 108,JAPAN
关键词
D O I
10.1111/j.1348-0421.1991.tb02025.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We examined mouse immune response to 4 kinds of recombinant vaccinia viruses carrying the HIV gag gene, including vac-gag/pol, which produces HIV-like particles with processed gag proteins; vac-gag, which also produces HIV-like particles but with unprocessed gag protein; and vac-gag-pol-fuse and vac-es-gag/pol, neither of which produces such particles but releases reverse transcriptase and gag protein, respectively, from infected cells. Although infection of mice with recombinant vaccinia viruses induced production of the anti-p24 antibody in all mice, vac-gag/pol and vac-es-pol induced higher production than the other two recombinants. Increase in [H-3]thymidine uptake by splenic lymphocytes following p24 antigen stimulation was most evident in mice infected with vac-gag/pol. Thus, the highest immune reaction, both humoral and cellular, was elicited by vac-gag/pol, indicating that among those tested, this recombinant vaccinia virus is the best candidate for a vaccine that induces anti-HIV gag immunity.
引用
收藏
页码:849 / 861
页数:13
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