Extremely low-dose vigabatrin for West syndrome with tuberous sclerosis

被引：0

作者：

Hino-Fukuyo, Naomi ^{[1
]}

Sato, Yuko ^{[1
]}

Kakisaka, Yosuke ^{[1
]}

Endo, Wakaba ^{[1
]}

Kubota, Yuki ^{[1
]}

Kikuchi, Atsuo ^{[1
]}

Kobayashi, Tomoko ^{[1
]}

Haginoya, Kazuhiro ^{[1
,2
]}

Uematsu, Mitsugu ^{[1
]}

Numata, Yurika ^{[1
]}

Doi, Hiroshi ^{[3
]}

Mori, Masato ^{[4
]}

Osaka, Hitoshi ^{[3
,4
]}

Kure, Shigeo ^{[1
]}

机构：

[1] Tohoku Univ, Sch Med, Dept Pediat, Sendai, Miyagi, Japan

[2] Takuto Rehabil Ctr Children, Dept Pediat Neurol, Sendai, Miyagi, Japan

[3] Tohoku Univ, Sch Med, Dept Ophthalmol, Sendai, Miyagi, Japan

[4] Jichi Med Univ, Sch Med, Dept Pediat, Yamanashi, Japan

来源：

JOURNAL OF PEDIATRIC EPILEPSY | 2013年 / 2卷 / 04期

关键词：

West syndrome; infantile spasms; tuberous screlosis complex; vigabatrin;

D O I：

10.3233/PEP-14064

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Treatment of west syndrome in patients with tuberous sclerosis, the relevant effective period and doses of vigabatrin (VGB) to avoid serious side effects still needs further investigation. We report on a Japanese girl who showed good results with a very low dose of VGB. Tonic spasms appeared at 5 mo of age. Adrenocorticotropic hormone therapy resulted in incomplete seizure control. VGB at the lowest practical dose (30 mg/kg/d) showed complete control after 3 d. With reduction of the dose to 10 mg/kg/d, side effects such as hyperactivity, irritability, and sleep disturbances improved. She was seizure- free for the next 6 mo with an improved developmental quotient. Ophthalmological evaluation revealed no abnormality. The present case illustrates that low- dose VGB therapy (10 mg/kg/d) has fewer side effects and may bring prompt seizure control in west syndrome with tuberous sclerosis.

引用

页码：255 / 258

页数：4

共 50 条

[31] Long-term course of West syndrome associated with tuberous sclerosis
Fukushima, K
Inoue, Y
Fujiwara, T
Yagi, K
EPILEPSIA, 1998, 39 : 50 - 54
[32] Efficacy and safety of vigabatrin in patients with tuberous sclerosis complex and infantile epileptic spasm syndrome: a systematic review
Prezioso, Giovanni
Chiarelli, Francesco
Matricardi, Sara
EXPERT REVIEW OF NEUROTHERAPEUTICS, 2023, 23 (07) : 661 - 671
[33] Low-Dose Naltrexone for Pruritus in Systemic Sclerosis
Frech, Tracy
Novak, Kirsten
Revelo, Monica P.
Murtaugh, Maureen
Markewitz, Boaz
Hatton, Nathan
Scholand, Mary Beth
Frech, Edward
Markewitz, David
Sawitzke, Allen D.
INTERNATIONAL JOURNAL OF RHEUMATOLOGY, 2011, 2011
[34] Efficacy and tolerability of vigabatrin in West syndrome
Moraes, MHP
Montenegro, MA
Franzon, RC
Avila, JO
Guerreiro, MM
ARQUIVOS DE NEURO-PSIQUIATRIA, 2005, 63 (2B) : 469 - 473
[35] A case of West syndrome well controlled by very short and low-dose ACTH therapy
Kimura, M
Miyamoto, S
Sejima, H
Yamaguchi, S
PSYCHIATRY AND CLINICAL NEUROSCIENCES, 1999, 53 (01) : 67 - 70
[36] Serotonin syndrome with low-dose escitalopram
Ozturk, Nese
Kara, Ezgi
Sozeri-Varma, Gulfizar
Degirmenci, Eylem
JOURNAL OF MOOD DISORDERS, 2013, 3 (01) : 37 - 40
[37] LOW-DOSE OF LITHIUM IN FELTYS SYNDROME
REVUELTA, JRT
RUIZ, MM
SEGUI, GL
VANO, JIP
MEDICINA CLINICA, 1988, 91 (03): : 118 - 119
[38] LOW-DOSE METHOTREXATE FOR THE SEZARY SYNDROME
ZACKHEIM, HS
EPSTEIN, EH
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1989, 21 (04) : 757 - 762
[39] LOW-DOSE PREDNISOLONE IN NEPHROTIC SYNDROME
CHOONARA, IA
HENEY, D
MEADOW, SR
ARCHIVES OF DISEASE IN CHILDHOOD, 1989, 64 (04) : 610 - 611
[40] Low-dose decitabine for myelodysplastic syndrome
Baker, Holly
LANCET ONCOLOGY, 2013, 14 (08): : E299 - E299

← 1 2 3 4 5 →