Herbal drugs and drug interactions

被引:10
|
作者
Dulger, Gul [1 ]
机构
[1] Marmara Univ, Eczacil, Istanbul, Turkey
关键词
StJohn's wort; garlic; ginkgo; ginger; ginseng;
D O I
10.12991/201216415
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Herbal drugs are defined as any form of a plant or plant product that contains a single herb or combinations of herbs that are believed to have complementary effects. Although they are considered to be safe, because they are natural, they may have various adverse effects, and may interact with other herbal products or conventional drugs. These interactions are especially important for drugs with narrow therapeutic indices. In the present study, pharmacokinetic and pharmacodynamic interactions of some most commanly used herbals (St John's wort, ginkgo biloba, ginseng, ginger, garlic, echinacea, ephedra and valerian) with the conventional drugs were reviewed. Pharmacokinetic interactions involve mainly induction or inhibition of the cytochrome P450 isozymes and p-glycoproteins by the herbal medicine, thus changing the absorption and/or elimination rate and consequently the efficacy of the concommitantly used drugs. St John's wort, a well known enzyme inducer, decreases the efficacy of most of the other drugs that are known to be the substrates of these enzymes. Pharmacodynamic interactions may be due to additive or synergistic effects which results in enhanced effect or toxicity, or herbal medicines with antagonistic properties reduce drug efficacy and result in therapeutic failure. For exampla, St John's wort may have synergistic effects with other antidepressant drugs used by the patient, resulting in increased CNS effects. Herbals like ginseng, ginkgo, garlic, ginger were reported to increase bleeding time, thus potentiating the effect of anticoagulant and antithrombotic agents. In conclusion, patients should be warned against the interaction between the herbal products and conventional medicines.
引用
收藏
页码:9 / 22
页数:14
相关论文
共 50 条
  • [21] Drug interactions between herbal and prescription medicines
    Williamson, EM
    [J]. DRUG SAFETY, 2003, 26 (15) : 1075 - 1092
  • [22] Herbal remedies -: a potential source of drug interactions
    Mörike, K
    Gleiter, CH
    [J]. INTERNIST, 2003, 44 (06): : 748 - 752
  • [23] Herbal medication: potential for adverse interactions with analgesic drugs
    Abebe, W
    [J]. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2002, 27 (06) : 391 - 401
  • [24] Pharmacokinetic interactions between antiretroviral drugs and herbal medicines
    Lamorde, Mohammed
    Byakika-Kibwita, Pauline
    Merry, Concepta
    [J]. BRITISH JOURNAL OF HOSPITAL MEDICINE, 2012, 73 (03) : 132 - 136
  • [25] Interactions of antithrombotic herbal medicines with Western cardiovascular drugs
    Zuo, Hua-Li
    Linghu, Ke-Gang
    Wang, Ya-Li
    Liu, Kun-Meng
    Gao, Yan
    Yu, Hua
    Yang, Feng-Qing
    Hu, Yuan-Jia
    [J]. PHARMACOLOGICAL RESEARCH, 2020, 159
  • [26] Herbal Interactions with Anticancer Drugs: Mechanistic and Clinical Considerations
    Yang, An-Kui
    He, Shu-Ming
    Liu, Liang
    Liu, Jun-Ping
    Wei, Ming Qian
    Zhou, Shu-Feng
    [J]. CURRENT MEDICINAL CHEMISTRY, 2010, 17 (16) : 1635 - 1678
  • [27] Potential of pharmacokinetic profiling for detecting herbal interactions with drugs
    Butterweck, Veronika
    Derendorf, Hartmut
    [J]. CLINICAL PHARMACOKINETICS, 2008, 47 (06) : 383 - 397
  • [28] Herbal medicine: Potential for intoxication and interactions with conventional drugs
    Poppenga, RH
    [J]. CLINICAL TECHNIQUES IN SMALL ANIMAL PRACTICE, 2002, 17 (01): : 6 - 18
  • [29] Potential of Pharmacokinetic Profiling for Detecting Herbal Interactions with Drugs
    Veronika Butterweck
    Hartmut Derendorf
    [J]. Clinical Pharmacokinetics, 2008, 47 : 383 - 397
  • [30] Interactions between Herbal Medicinal Products and Conventional Drugs
    Cvek, J.
    Balazin, A.
    Tomic, S.
    [J]. KEMIJA U INDUSTRIJI-JOURNAL OF CHEMISTS AND CHEMICAL ENGINEERS, 2011, 60 (06): : 343 - 349