EVIDENCE FOR THE NEOPLASTIC INVOLVEMENT OF MONOCYTIC, EOSINOPHILIC AND BASOPHILIC LINEAGES IN ACUTE MYELOMONOCYTIC LEUKEMIA WITH EOSINOPHILIA

被引：8
|
作者：
YANAGISAWA, K [1 ]
FUKUOKA, T [1 ]
FUJITA, S [1 ]
机构：
[1] EHIME COLL HLTH SCI,DEPT LAB MED,EHIME,JAPAN
来源：
ACTA HAEMATOLOGICA | 1990年 / 83卷 / 03期
关键词：
Acute myelomonocytic leukemia with eosinophilia (M[!sub]4[!/sub]E[!sub]0[!/sub]); Chromosome abnormality; inv(16)(p13q22); Leukemic precursors;
D O I：
10.1159/000205192
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
To investigate the origin of cells observed in acute myelomonocytic leukemia with eosinophilia (M4E0), we carried out morphological and cytogenetic studies of colonies derived from leukemic precursors. Marrow cells from a patient with M4E0 at second relapse revealed an abnormal karyotype; 47,XY, +8, inv(16)(p13q22), 17p-. Cytogenetic studies of leukemic colonies showed the same karyotypic abnormality. The primary and secondary colonies consisted of monocytes, eosinophils and basophils. These results indicated that the neoplastic process in this patient originated in a stem cell capable of differentiation into at least monocytes, eosinophils and basophils.
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收藏
页码：145 / 148
页数：4
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