ANTITUMOR-ACTIVITY OF 5-FLUOROURACIL, VERAPAMIL AND HYPERTHERMIA AGAINST HUMAN GASTRIC ADENOCARCINOMA CELL (AGS) IN-VITRO

被引：0
|
作者：
SCHCHEPOTIN, IB [1 ]
SHABAHANG, M [1 ]
NAUTA, RJ [1 ]
BURAS, RR [1 ]
BRENNER, RV [1 ]
EVANS, SRT [1 ]
机构：
[1] GEORGETOWN UNIV,DEPT SURG,LOBARDI CANC CTR,PHC-4,3800 RESERVOIR RD,WASHINGTON,DC 20007
来源：
SURGICAL ONCOLOGY-OXFORD | 1994年 / 3卷 / 05期
关键词：
5-FLUOROURACIL; GASTRIC CANCER; HYPERTHERMIA; VERAPAMIL;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The purpose of this study was to assess the efficacy of verapamil (20 muM) and hyperthermia (42-degrees-C) as modifiers of 5-fluorouracil (5-FU), used at different concentrations, in inhibiting the growth of gastric adenocarcinoma cells. Combined verapamil and hyperthermia treatment showed a significant decrease in cell count when compared to control (72.2%), hyperthermia alone (68.4%), or verapamil alone (65%). At a high concentration of 5-FU (50 mug/ml), verapamil and hyperthermia had an additive growth inhibitory effect over a 4-day period when compared to control. A combination of 5-FU at low concentration (0.5 mug/ml) with verapamil significantly suppressed growth by 31.2% in comparison to control - with this effect being independent of the duration of treatment. The modalities analysed in this study require further investigation and have potential for clinical applicability to gastric cancer therapy in the future.
引用
收藏
页码：287 / 294
页数：8
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