HYPERVALENT IODINE IN ORGANIC-SYNTHESIS - ONE-POT FACILE SYNTHESES OF ALPHA-THIOCYANATOACETOPHENONES, 2-HYDROXY-4-ARYLTHIAZOLES, AND 2-MERCAPTO-4-ARYLTHIAZOLES USING [HYDROXY (TOSYLOXY)IODO]BENZENE

被引：33
|
作者：
PRAKASH, O
SAINI, N
机构：
[1] Department of Chemistry, Kurukshetra University
来源：
SYNTHETIC COMMUNICATIONS | 1993年 / 23卷 / 10期
关键词：
D O I：
10.1080/00397919308011236
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Hypervalent iodine oxidation of acetophenones (1a-1e) with [hydroxy(tosyloxy)iodo] benzene, followed by treatment with potassium thiocyanate offers a new facile synthesis of corresponding alpha-thiocyanatoacetophenones (3a-3e). Cyclization of 3a-3e, thus generated in situ, using AcOH/H2O and H2NC(S)NH2/HCl provides one pot facile syntheses of 2-hydroxy-, and 2-mercapto-4-arylthiazoles (4 & 5) respectively.
引用
收藏
页码：1455 / 1462
页数：8
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