The accuracy of warfarin dosage based on VKORC1 and CYP2C9 phenotypes in a Chinese population

被引：0
|
作者：
Wijaya, Agustinus [1 ]
Bo, Jiang T. [1 ]
Jun, He [2 ]
Ping, Jiang W. [1 ]
Bin, Jiang [1 ]
Jie, Chen H. [2 ]
Wen, Yang B. [1 ]
Zhu, Xu M. [1 ]
Cheng, Qiu Q. [2 ]
机构：
[1] Soochow Univ, Affiliated Hosp 1, Dept Cardiovasc Dis, Suzhou, Jiangsu, Peoples R China
[2] Soochow Univ, Affiliated Hosp 1, Dept Haematol, Suzhou, Jiangsu, Peoples R China
来源：
MEDICAL JOURNAL OF INDONESIA | 2012年 / 21卷 / 02期
关键词：
CYP2C9; pharmacogenetic algorithm; VKORC1; warfarin;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: The aim of this study is to assess the accuracy of warfarin dosage based on VKORC1 and CYP2C9 genotype in Chinese population. Methods: Blood samples were taken from 37 patients. We compared the warfarin dosage obtained from genotype ( according to www. warfarindosing. org) and treatment dosage with international normalized ratio (INR) value within 2.0-3.0. Results: The majority of Chinese people in our study are VKORC1 homozygous AA (89.2%), rarely VKORC1 heterozygous AG and we cannot find a patient with homozygous GG. For CYP2C9 genotype, most patients have the wildtype variants (CYP2C9*2 CC and CYP2C9*3 AA). The warfarin dosage for patients with VKORC1 AA and CYP2C9*3 AC is lower than for patients with other genotype variants. Conclusion: There is no significant difference between pharmacogenetic algorithm (www. warfarindosing. org) and our treatment dosage. Our conclusion is that the pharmacogenetic algorithm is accurate to predict the warfarin dose.
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收藏
页码：108 / 112
页数：5
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