PALLADIUM-CATALYZED SYNTHESIS OF NEW UNSATURATED EXO-ENOL LACTONES WITH POTENTIAL BIOLOGICAL-ACTIVITY

被引：45
|
作者：
BOUYSSI, D [1 ]
GORE, J [1 ]
BALME, G [1 ]
LOUIS, D [1 ]
WALLACH, J [1 ]
机构：
[1] UNIV LYON 1,CNRS,BIOCHIM ANALYT LAB,F-69622 VILLEURBANNE,FRANCE
来源：
TETRAHEDRON LETTERS | 1993年 / 34卷 / 19期
关键词：
D O I：
10.1016/S0040-4039(00)93397-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Various allenenols lactones [5(E)-(2-allenylidene)-tetrahydro-2-furanones] have been synthesized by reacting 4-pentynoic acid and 2-alkynyl acetate in dimethyl sulfoxide in the presence of K2CO3, Pd(OAc)2 as the catalyst and tri(2-furyl) phosphine as the ligand. The biological activity of these compounds as protease inhibitors has been proven.
引用
收藏
页码：3129 / 3130
页数：2
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