RENAL COMPLICATIONS OF INTRAVESICAL BACILLUS CALMETTE-GUERIN THERAPY

被引：24
|
作者：
MODESTO, A
MARTY, L
SUC, JM
KLEINKNECHT, D
DEFREMONT, JF
MARSEPOIL, T
VEYSSIER, P
机构：
[1] CTR HOSP,DEPT NEPHROL,56 BD BOISSIER,F-93105 MONTRUEIL,FRANCE
[2] UNIV RANGUEIL,DEPT IMMUNOL,TOULOUSE,FRANCE
[3] UNIV RANGUEIL,DEPT NEPHROL,TOULOUSE,FRANCE
[4] HOSP CARCASSONNE,DEPT NEPHROL,CARCASSONNE,FRANCE
[5] POLYCLIN ST COME,COMPIEGNE,FRANCE
[6] HOSP COMPEIGNE,DEPT MED,COMPIEGNE,FRANCE
[7] HOSP GONESSE,INTENS CARE UNIT,GONESSE,FRANCE
来源：
AMERICAN JOURNAL OF NEPHROLOGY | 1991年 / 11卷 / 06期
关键词：
BACILLUS CALMETTE-GUERIN; RENAL GRANULOMAS; IMMUNE-COMPLEX GLOMERULONEPHRITIS; BLADDER CANCER;
D O I：
10.1159/000168368
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
We report 3 patients who developed signs of systemic infection and renal insufficiency after intravesical bacillus Calmette-Guerin (BCG) instillations for a bladder cancer. Renal biopsy showed tubulo-interstitial nephritis with or without epithelioid granulomas in 2 cases, and mesangial glomerulonephritis in the last case. All patients had granulomatous hepatitis in association. It seems that hematogenous dissemination via a traumatic instillation of BCG and/or an immune-complex mechanism may have contributed to the renal damage, which was only partially reversible in 2 patients.
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页码：501 / 504
页数：4
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