UTEROFERRIN HAS N-ASPARAGINE-LINKED HIGH-MANNOSE-TYPE OLIGOSACCHARIDES THAT CONTAIN MANNOSE 6-PHOSPHATE

Uteroferrin is an Fe-containing, progesterone-induced, acid phosphatase that is secreted in large amounts by the uterine endometrium of pigs. During pregnancy, it transports iron across the chorioallantois (placenta) for use in fetal hematopoiesis. Uteroferrin synthesized by cultured endometrial explants possesses N-linked, high-mannose, oligosaccharide chains that contain 6-phosphomannose units. The latter is regarded as a possible recognition marker whereby acid hydrolases are targeted to the lysosome. On uteroferrin, however, the majority of the phosphate is in single diester linkages between the mannose and a covering N-acetylglucosamine. Uteroferrin may be a lysosomal enzyme that has assumed a role in Fe transport and metabolism and is secreted because the covering N-acetylglucosamine is not removed.