GROWTH-INHIBITION OF HUMAN PANCREATIC-CANCER CELLS BY CHOLECYSTOKININ RECEPTOR ANTAGONIST IN TISSUE-CULTURE AND IN NUDE-MICE

被引：0
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作者：
FUNAKOSHI, A
KONO, A
机构：
来源：
GASTROENTEROLOGIA JAPONICA | 1992年 / 27卷 / 01期
关键词：
CCK; CR-1505; PANCREATIC CANCER CELL LINE;
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The Human pancreatic carcinoma cell line KP-1N and its clone KP-1NL which has a high rate of liver metastasis were established. Ki-ras DNA point mutation on the codon 12 was found. The growth of KP-1N was stimulated by a physiological range of concentration (10(-11)-10(-10) M) of cholecystokinin and the increase was inhibited by the addition of a cholecystokinin receptor antagonist (CR 1505). Daily injections of CR 1505 (35 mg/kg) diminished the number of tumor colonies in the liver that were formed after an intrasplenic injection of the highly liver metastatic KP-1NL cells. These results suggest that cholecystokinin antagonists may be useful as growth inhibitors for some pancreatic cancer.
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页码：78 / 82
页数：5
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