EFFECTS OF THE ANTIDEPRESSANT DRUG TIANEPTINE ON PLASMA AND PLATELET SEROTONIN CONCENTRATIONS IN THE RAT

被引：31
|
作者：
ORTIZ, J
MOCAER, E
ARTIGAS, F
机构：
[1] CSIC,DEPT NEUROCHEM,JORDI GIRONA 18-26,E-08034 BARCELONA,SPAIN
[2] INST RECH INT SERVIER,F-92202 NEUILLY SUR SEINE,FRANCE
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 199卷 / 03期
关键词：
ANTIDEPRESSANTS; TIANEPTINE; 5-HT UPTAKE; PLASMA; PLATELETS; 5-HT SYNTHESIS;
D O I：
10.1016/0014-2999(91)90497-E
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The antidepressant drug tianeptine increased rat plasma 5-hydroxyindoleacetic (5-HIAA) concentrations after single and repeated treatment for 14 days. This effect was not due to an increase in 5-hydroxytryptamine (5-HT) synthesis, as measured by the accumulation of 5-hydroxytryptophan in plasma and brain. A concurrent decrease in platelet-free plasma 5-HT concentrations occurred after subchronic treatment. Tianeptine attenuated the large increase in 5-HT concentrations in platelet-free plasma elicited by the specific 5-HT uptake inhibitors citalopram and paroxetine. These data are compatible with the reported 5-HT uptake-enhancing activity of this antidepressant drug.
引用
收藏
页码：335 / 339
页数：5
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