FORMULATION AND IN-VITRO EVALUATION OF FLOATING EFFERVESCENT TABLETS OF RANITIDINE HYDROCHLORIDE

The main objective of the present work is to develop Floating Effervescent matrix tablets of Ranitidine hydrochloride using different polymers viz. hydroxy propyl methyl cellulose ( HPMC), Xanthan gum and Guar gum. Varying ratios of drug and polymer like 1: 0.6 and 1: 1 were selected for the study. After fixing the ratio of drug and polymer for control the release of drug up to desired time, the release rates were modulated by combination of two different rate controlling material. After evaluation of physical properties of tablet, in-vitro buoyancy studies, Swelling index and in vitro release study were performed in 0.1N Hcl up to 12 hrs. Dissolution data was analyzed by Korsmeyer-Peppas power law expression and modified power law expression. It was observed that matrix tablets contained polymer blend of HPMC K100M/Guar gum were successfully sustained the release of drug upto 12 hrs. Among all the formulations, formulation F9 which contains 50% HPMC K100M and 50% of Guar gum has released the drug which follow Zero order kinetics via, swelling, diffusion and erosion. The release profile of formulation F9 was comparable with the marketed product. The FTIR study revealed that there was no chemical interaction between drug and excipients.