METABOLISM OF ANTI-TUMOUR AGENT 5-(1-AZIRIDINYL)-2,4-DINITROBENZAMIDE (CB 1954)

被引：20
|
作者：
JARMAN, M [1 ]
MELZACK, DH [1 ]
ROSS, WCJ [1 ]
机构：
[1] ROY CANC HOSP,INST CANC RES,CHESTER BEATTY RES INST,SUTTON,SURREY,ENGLAND
来源：
BIOCHEMICAL PHARMACOLOGY | 1976年 / 25卷 / 22期
关键词：
D O I：
10.1016/0006-2952(76)90451-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：2475 / 2478
页数：4
相关论文
共 50 条
  • [31] Hypoxia-selective antitumor agents .14. Synthesis and hypoxic cell cytotoxicity of regioisomers of the hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide
    Palmer, BD
    Wilson, WR
    Anderson, RF
    Boyd, M
    Denny, WA
    JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (13) : 2518 - 2528
  • [32] COMPOUNDS WITH ELECTROPHILIC REACTIVITY .6. SYNTHESIS AND PROPERTIES OF 2-[2,4-BIS(1-AZIRIDINYL)-1,3,5-TRIAZIN-6-YL]AMINO-1,3-PROPANEDIOLS AND 2,2-DIMETHYL-5-[2,4-BIS(1-AZIRIDINYL)-1,3,5-TRIAZIN-6-YL]AMINO-1,3-DIOXANES
    KRAIZ, BO
    REMIZOV, AL
    ZHURNAL ORGANICHESKOI KHIMII, 1979, 15 (06): : 1282 - 1289
  • [33] INTERACTION OF ANTI-TUMOUR DRUG CIS-PT(EN)CL2 WITH CYTIDILYL-3'-]5-]GUANOSINE
    JORDANOV, J
    WILLIAMS, RJP
    BIOINORGANIC CHEMISTRY, 1978, 8 (01): : 77 - 82
  • [34] HYPOXIA-SELECTIVE ANTITUMOR AGENTS .9. STRUCTURE-ACTIVITY-RELATIONSHIPS FOR HYPOXIA-SELECTIVE CYTOTOXICITY AMONG ANALOGS OF 5-[N,N-BIS(2-CHLOROETHYL)AMINO]-2,4-DINITROBENZAMIDE
    PALMER, BD
    WILSON, WR
    ATWELL, GJ
    SCHULTZ, D
    XU, XZ
    DENNY, WA
    JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (14) : 2175 - 2184
  • [35] Metabolism and pharmacokinetics of the anti-tumour agent 2,3,5-trimethyl-6-(3-pyridylmethyl)1,4-benzoquinone (CV-6504)
    Hussey, HJ
    Tisdale, MJ
    BRITISH JOURNAL OF CANCER, 1996, 74 (09) : 1349 - 1353
  • [36] INVESTIGATIONS IN HETEROCYCLE SERIES .56. COMPOUNDS WITH ELECTROPHILIC REACTIVITY - SYNTHESIS AND PROPERTIES OF NEW 2,2-DIMETHYL-5-[2,4-BIS(1-AZIRIDINYL)-1,3,5-TRIAZINE-6-YL]AMINO-1,3-DIOXANES AND 2-[2,4-BIS(1-AZIRIDINYL)-1,3,5-TRIAZINE-6-YL]AMINO-1,3-PROPANEDIOLS
    KRAIZ, BO
    SHENBERG, NN
    IVIN, BA
    ZHURNAL ORGANICHESKOI KHIMII, 1985, 21 (02): : 419 - 427
  • [37] IDENTIFICATION, SYNTHESIS AND PROPERTIES OF 5-(AZIRIDIN-1-YL)-2-NITRO-4-NITROSOBENZAMIDE, A NOVEL DNA CROSS-LINKING AGENT DERIVED FROM CB1954
    KNOX, RJ
    FRIEDLOS, F
    BIGGS, PJ
    FLITTER, WD
    GASKELL, M
    GODDARD, P
    DAVIES, L
    JARMAN, M
    BIOCHEMICAL PHARMACOLOGY, 1993, 46 (05) : 797 - 803
  • [38] Identification and reactivity of the major metabolite (β-1-glucuronide) of the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in humans
    Zhou, SF
    Paxton, JW
    Tingle, ID
    Kestell, P
    Jameson, MB
    Thompson, PI
    Baguley, BC
    XENOBIOTICA, 2001, 31 (05) : 277 - 293
  • [39] N'-Formyl-2-(5-nitrothiophen-2-yl)benzothiazole-6-carbohydrazide as a potential anti-tumour agent for prostate cancer in experimental studies
    Rodrigues, Juan R.
    Charris, Jaime
    Camacho, Jose
    Barazarte, Arthur
    Gamboa, Neira
    Nitzsche, Bianca
    Hoepfner, Michael
    Lein, Michael
    Jung, Klaus
    Abramjuk, Claudia
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2013, 65 (03) : 411 - 422
  • [40] Crystal structure of creatininium 5-(2,4-dinitrophenyl)-1,3-dimethylbarbiturate monohydrate: a potential anticonvulsant agent
    Devi, Ponnusamy Poornima
    Kalaivani, Doraisamyraja
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2016, 72 : 620 - +
12345